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单倍体人类胚胎干细胞:一半的基因组,双倍的价值。

Haploid Human Embryonic Stem Cells: Half the Genome, Double the Value.

机构信息

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

出版信息

Cell Stem Cell. 2016 Nov 3;19(5):569-572. doi: 10.1016/j.stem.2016.10.009.

Abstract

Recent advances in the generation of haploid embryonic stem cells (ESCs), capable of self-renewal and differentiation, have laid the groundwork for numerous biomedical applications in developmental biology and reproductive medicine. When combined with the power of genetic screening, haploid human ESCs could advance cancer research, regenerative medicine, and disease modeling.

摘要

最近在单倍体胚胎干细胞(ESCs)的生成方面取得了进展,这些细胞具有自我更新和分化的能力,为发育生物学和生殖医学中的许多生物医学应用奠定了基础。当与遗传筛选的力量结合使用时,人类单倍体 ESC 可以推进癌症研究、再生医学和疾病建模。

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