Department of Chemical and Biochemical Engineering, Faculty of Engineering, Western University, London, ON N6A 5B9, Canada.
Department of Chemical and Biochemical Engineering, Faculty of Engineering, Western University, London, ON N6A 5B9, Canada.
Biotechnol Adv. 2016 Dec;34(8):1396-1412. doi: 10.1016/j.biotechadv.2016.10.005. Epub 2016 Nov 2.
Carotenoids have been receiving increasing attention due to their potential health benefits. Microalgae are recognized as a natural source of carotenoids and other beneficial byproducts. However, the production of micro-algal carotenoids is not yet sufficiently cost-effective to compete with traditional chemical synthetic methods and other technologies such as extraction from plant based sources. This review presents the recent biotechnological developments in microalgal carotenoid production. The current technologies involved in their bioprocessing including cultivation, harvesting, extraction, and purification are discussed with a specific focus on downstream processing. The recent advances in chemical and biochemical synthesis of carotenoids are also reviewed for a better understanding of suitable and economically feasible biotechnological strategies. Some possible future directions are also proposed.
类胡萝卜素由于其潜在的健康益处而受到越来越多的关注。微藻被认为是类胡萝卜素和其他有益副产品的天然来源。然而,微藻类胡萝卜素的生产还不够经济实惠,无法与传统的化学合成方法和其他技术(如从植物来源提取)竞争。本综述介绍了微藻类胡萝卜素生产的最新生物技术发展。讨论了涉及它们的生物加工的当前技术,包括培养、收获、提取和纯化,特别关注下游加工。还综述了类胡萝卜素的化学和生物化学合成的最新进展,以便更好地理解合适且经济可行的生物技术策略。还提出了一些可能的未来方向。