Luo Ting, Zhang Zhen, Xu Junbo, Liu Hanxiong, Cai Lin, Huang Gang, Wang Chunbin, Chen Yingzhong, Xia Long, Ding Xunshi, Wang Jin, Li Xin
Department of Cardiology, The Third People's Hospital of Chengdu Affiliated to Southwest Jiaotong University, Key Laboratory of Advanced Technologies of Materials Ministry of Education, Southwest Jiaotong University, Chengdu, Sichuan, China.
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.
Front Bioeng Biotechnol. 2023 Jun 19;11:1205751. doi: 10.3389/fbioe.2023.1205751. eCollection 2023.
Cardiovascular disease (CVDs) is the first killer of human health, and it caused up at least 31% of global deaths. Atherosclerosis is one of the main reasons caused CVDs. Oral drug therapy with statins and other lipid-regulating drugs is the conventional treatment strategies for atherosclerosis. However, conventional therapeutic strategies are constrained by low drug utilization and non-target organ injury problems. Micro-nano materials, including particles, liposomes, micelles and bubbles, have been developed as the revolutionized tools for CVDs detection and drug delivery, specifically atherosclerotic targeting treatment. Furthermore, the micro-nano materials also could be designed to intelligently and responsive targeting drug delivering, and then become a promising tool to achieve atherosclerosis precision treatment. This work reviewed the advances in atherosclerosis nanotherapy, including the materials carriers, target sites, responsive model and treatment results. These nanoagents precisely delivery the therapeutic agents to the target atherosclerosis sites, and intelligent and precise release of drugs, which could minimize the potential adverse effects and be more effective in atherosclerosis lesion.
心血管疾病（CVDs）是人类健康的头号杀手，其导致的全球死亡人数至少占比31%。动脉粥样硬化是引发心血管疾病的主要原因之一。使用他汀类药物和其他调脂药物进行口服药物治疗是动脉粥样硬化的传统治疗策略。然而，传统治疗策略受到药物利用率低和非靶器官损伤问题的限制。包括颗粒、脂质体、胶束和气泡在内的微纳米材料已被开发成为用于心血管疾病检测和药物递送的变革性工具，特别是用于动脉粥样硬化靶向治疗。此外，微纳米材料还可以被设计成智能响应性靶向药物递送，进而成为实现动脉粥样硬化精准治疗的有前景的工具。这项工作综述了动脉粥样硬化纳米治疗的进展，包括材料载体、靶点、响应模型和治疗结果。这些纳米制剂将治疗剂精确递送至动脉粥样硬化靶点，并实现药物的智能精准释放，从而可以将潜在的不良反应降至最低，并且在动脉粥样硬化病变中更有效。
