Takeoka Atsushi, Tayama Jun, Yamasaki Hironori, Kobayashi Masakazu, Ogawa Sayaka, Saigo Tatsuo, Kawano Hiroaki, Abiru Norio, Hayashida Masaki, Maeda Takahiro, Shirabe Susumu
Unit of Preventive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Graduate School of Education, Nagasaki University, Nagasaki, Japan Department of Endocrinology and Metabolism, Sasebo City General Hospital, Sasebo, Japan Center for Health and Community Medicine, Nagasaki University, Nagasaki, Japan Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Department of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Unit of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Medicine (Baltimore). 2016 Nov;95(45):e5361. doi: 10.1097/MD.0000000000005361.
Accumulation of intra-abdominal fat is related to hypertension. Despite this, a relationship between hypertension and intra-abdominal fat in young adulthood is not clear. In this study, we verify whether intra-abdominal fat accumulation increases a hypertension risk in young adult subjects.In a cross-sectional study, intra-abdominal fat area was measured using a dual bioelectrical impedance analysis instrument in 697 university students (20.3 ± 0.7 years, 425 men). Blood pressure and anthropometric factors were measured. Lifestyle variables including smoking, drinking, physical activity, and eating behavior were assessed with questionnaire. High blood pressure risk (systolic blood pressure ≥130 mm Hg and/or diastolic blood pressure ≥85 mm Hg) with increasing intra-abdominal fat area was evaluated.Participants were divided into 5 groups according to their intra-abdominal fat area (≤24.9, 25-49.9, 50-74.9, 75-99.9, and ≥100 cm). As compared with the values of the smallest intra-abdominal fat area group, the crude and lifestyle-adjusted odds ratios (ORs) were elevated in larger intra-abdominal fat area groups [OR 1.31, 95% confidence interval (CI) 0.66-2.80; OR 3.38, 95% CI 1.60-7.57; OR 7.71, 95% CI 2.75-22.22; OR 18.74, 95% CI 3.93-105.64, respectively). The risk increase was observed only in men.Intra-abdominal fat accumulation is related to high blood pressure in men around 20 years of age. These results indicate the importance of evaluation and reduction of intra-abdominal fat to prevent hypertension.
腹内脂肪堆积与高血压有关。尽管如此，年轻成年期高血压与腹内脂肪之间的关系尚不清楚。在本研究中，我们验证腹内脂肪堆积是否会增加年轻成年受试者患高血压的风险。在一项横断面研究中，使用双频生物电阻抗分析仪对697名大学生（20.3±0.7岁，425名男性）测量腹内脂肪面积。测量血压和人体测量学因素。通过问卷评估包括吸烟、饮酒、身体活动和饮食行为在内的生活方式变量。评估随着腹内脂肪面积增加的高血压风险（收缩压≥130 mmHg和/或舒张压≥85 mmHg）。参与者根据其腹内脂肪面积分为5组（≤24.9、25 - 49.9、50 - 74.9、75 - 99.9和≥100 cm）。与腹内脂肪面积最小组的值相比，腹内脂肪面积较大组的粗比值比（OR）和经生活方式调整后的比值比升高[分别为OR 1.31，95%置信区间（CI）0.66 - 2.80；OR 3.38，95% CI 1.60 - 7.57；OR 7.71，95% CI 2.75 - 22.22；OR 18.74，95% CI 3.93 - 105.64]。仅在男性中观察到风险增加。腹内脂肪堆积与20岁左右男性的高血压有关。这些结果表明评估和减少腹内脂肪对预防高血压的重要性。
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