Department of Family Medicine, Yonsei University College of Medicine, Gang-nam Severance Hospital, Seoul, South Korea.
Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul, South Korea.
J Clin Hypertens (Greenwich). 2019 Dec;21(12):1849-1857. doi: 10.1111/jch.13723. Epub 2019 Oct 29.
Hypertension is strongly correlated with an increased risk of cardiovascular events. Recent studies have demonstrated that body fat percentage (BF%) is associated with cardiometabolic risk factors. The aim of this study was to investigate the association between a change in BF% and body mass index (BMI) and the incidence of new-onset hypertension in a normotensive Korean cohort. At baseline (2001-2002), 8848 participants aged 40-70 years were recruited for the study; follow-up surveys were completed in the year 2012. A total of 3902 adults (1866 men and 2036 women) were included in the final analysis. These subjects were divided into quartile groups according to changes in BF% and were followed for 8.4 years to monitor for the development of hypertension. A Poisson regression model was used to evaluate the relative risk (RR) for hypertension according to BF% change quartile. Additionally, we also stratified participants into four groups according to BMI change levels and body fat change levels. Finally, we compared two factors, BF% change, and BMI change, to determine which is more predictive of incident hypertension. In an adjusted model, compared with the lowest BF% quartile group, the risk of new-onset hypertension significantly increased with BF% change: Changes in risk were 0%-2.0% for quartile 3 subjects (RR: 1.32 [1.06-1.63]) and 2.0%-8.9% for quartile 4 participants (RR: 1.78 [1.43-2.19]). We also revealed that the RR for new-onset hypertension was 1.81 (95% CI: 1.47-2.21) for quartile 4 group subjects, compared with subjects in quartile 1 (change in BMI -6.80 to -0.86% [kg/m ]). Body fat gain and BMI increase were predictors of hypertension in this community-based Korean cohort.
高血压与心血管事件风险增加密切相关。最近的研究表明，体脂百分比（BF%）与心血管代谢危险因素有关。本研究旨在探讨 BF%和体重指数（BMI）变化与新诊断高血压的发生在一个正常血压的韩国队列中的相关性。在基线（2001-2002 年）时，招募了 8848 名年龄在 40-70 岁的参与者进行研究；在 2012 年完成了随访调查。共有 3902 名成年人（1866 名男性和 2036 名女性）被纳入最终分析。这些受试者根据 BF%的变化分为四分位组，并随访 8.4 年，以监测高血压的发生。使用泊松回归模型评估根据 BF%变化四分位组的高血压相对风险（RR）。此外，我们还根据 BMI 变化水平和体脂变化水平将参与者分为四组。最后，我们比较了 BF%变化和 BMI 变化两个因素，以确定哪个因素对新发高血压更具预测性。在调整模型中，与最低 BF%四分位组相比，BF%变化与新发高血压的风险显著增加：风险变化在第 3 四分位组为 0%-2.0%（RR：1.32[1.06-1.63]），第 4 四分位组为 2.0%-8.9%（RR：1.78[1.43-2.19]）。我们还发现，与第 1 四分位组相比，第 4 四分位组的新发高血压 RR 为 1.81（95%CI：1.47-2.21）（BMI 变化-6.80 至-0.86%[kg/m ]）。在这个基于社区的韩国队列中，体脂增加和 BMI 增加是高血压的预测因素。
