人类免疫缺陷病毒（HIV）与获得性免疫缺陷综合征（AIDS）患者的巨大特发性食管溃疡高度相关。
Human immunodeficiency virus (HIV) is highly associated with giant idiopathic esophageal ulcers in acquired immunodeficiency syndrome (AIDS) patients.
作者信息
Lv Bei, Cheng Xin, Gao Jackson, Zhao Hong, Chen Liping, Wang Liwei, Huang Shaoping, Fan Zhenyu, Zhang Renfang, Shen Yinzhong, Li Lei, Liu Baochi, Qi Tangkai, Wang Jing, Cheng Jilin
机构信息
Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University Shanghai, China.
Shanghai Jiaotong University Medical School Shanghai, China.
出版信息
Am J Transl Res. 2016 Oct 15;8(10):4464-4471. eCollection 2016.
OBJECTIVE
This study aimed to determine whether the human immunodeficiency virus (HIV) exists in giant idiopathic esophageal ulcers in the patients with acquired immune deficiency syndrome (AIDS).
METHODS
16 AIDS patients with a primary complaint of epigastric discomfort were examined by gastroscopy. Multiple and giant esophageal ulcers were biopsied and analyzed with pathology staining and reverse transcription-polymerase chain reaction (RT-PCR) to determine the potential pathogenic microorganisms, including HIV, cytomegalovirus (CMV) and herpes simplex viruses (HSV).
RESULTS
HIV was detected in ulcer samples from 12 out of these 16 patients. Ulcers in 2 patients were infected with CMV and ulcers in another 2 patients were found HSV positive. No obvious cancerous pathological changes were found in these multiple giant esophageal ulcer specimens.
CONCLUSION
HIV may be one of the major causative agents of multiple benign giant esophageal ulcers in AIDS patients.
目的
本研究旨在确定获得性免疫缺陷综合征（AIDS）患者的巨大特发性食管溃疡中是否存在人类免疫缺陷病毒（HIV）。
方法
对16例以中上腹不适为主诉的AIDS患者进行胃镜检查。对多发及巨大食管溃疡进行活检，并通过病理染色和逆转录聚合酶链反应（RT-PCR）分析，以确定潜在的致病微生物，包括HIV、巨细胞病毒（CMV）和单纯疱疹病毒（HSV）。
结果
这16例患者中有12例的溃疡样本检测出HIV。2例患者的溃疡感染了CMV，另外2例患者的溃疡HSV呈阳性。这些多发巨大食管溃疡标本中未发现明显的癌变病理改变。
结论
HIV可能是AIDS患者多发良性巨大食管溃疡的主要致病因素之一。
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