Lichterfeld M, Lorenz C, Nischalke H D, Scheurlen C, Sauerbruch T, Rockstroh J K
Department of General Internal Medicine, Rheinische Friedrich-Wilhelms-Universität, Bonn.
Z Gastroenterol. 2002 Jan;40(1):11-4. doi: 10.1055/s-2002-19637.
Various clinical studies indicated a lower prevalence of HP infection in HIV patients. The present study was initiated to determine whether the decreased frequency of HP infections in HIV patients might be associated with the stage of the underlying HIV disease or concomitant drug regimens the patients had received. 60 randomly selected HIV outpatients were stratified according to the stage of their HIV infection (CDC classification), their CD4 cell count and to the drug regimens they were given. Within these subgroups of patients, HP infection prevalence was separately investigated by serological and C13 breath testing. Data were compared to a reference population of 30 healthy volunteers. No difference in HP infection prevalence was found between the HIV infected patients in general and the reference cohort. A significantly lower proportion of HP infected individuals was observed among those HIV patients who had AIDS-defining diseases. Furthermore, a substantial but insignificant decrease of HP infection prevalence was noted in HIV patients with an extensive decline of CD4 cell count (< 100/microl). HIV patients who had received antimicrobial or H2-antagonizing drugs within 12 months prior to the study commencement also were found to have a remarkably decreased frequency of HP infections independently of their CD4 cell count. No association between HP infection prevalence and patients age, sex, risk group and the type of their antiretroviral treatment was found.We concluded from these results that the decreased HP infection prevalence in HIV patients may, apart from frequent antibiotic treatment, be correlated to the stage of HIV-mediated immune suppression.
多项临床研究表明，HIV患者中幽门螺杆菌（HP）感染的患病率较低。本研究旨在确定HIV患者中HP感染频率降低是否可能与潜在HIV疾病的阶段或患者接受的伴随药物治疗方案有关。根据HIV感染阶段（疾病控制与预防中心分类）、CD4细胞计数以及所接受的药物治疗方案，对60名随机选择的HIV门诊患者进行分层。在这些患者亚组中，通过血清学和C13呼气试验分别调查HP感染患病率。将数据与30名健康志愿者的参考人群进行比较。总体上，HIV感染患者与参考队列之间在HP感染患病率上未发现差异。在患有艾滋病界定疾病的HIV患者中，观察到HP感染个体的比例显著较低。此外，在CD4细胞计数大幅下降（<100/微升）的HIV患者中，HP感染患病率有大幅但不显著的下降。在研究开始前12个月内接受过抗菌药物或H2拮抗剂药物治疗的HIV患者，无论其CD4细胞计数如何，也发现HP感染频率显著降低。未发现HP感染患病率与患者年龄、性别、风险组及其抗逆转录病毒治疗类型之间存在关联。从这些结果中我们得出结论，HIV患者中HP感染患病率降低，除了频繁的抗生素治疗外，可能与HIV介导的免疫抑制阶段相关。
