Hew Jonathan, Solon-Biet Samantha M, McMahon Aisling C, Ruohonen Kari, Raubenheimer David, Ballard J William O, Le Couteur David G, Nicholls Caroline, Li Zhe, Maitz Peter K M, Wang Yiwei, Simpson Stephen J
Burns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
Ageing and Alzheimers Institute and ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia 2139.
PLoS One. 2016 Nov 10;11(11):e0166175. doi: 10.1371/journal.pone.0166175. eCollection 2016.
Nutrition influences skin structure; however, a systematic investigation into how energy and macronutrients (protein, carbohydrate and fat) affects the skin has yet to be conducted. We evaluated the associations between macronutrients, energy intake and skin structure in mice fed 25 experimental diets and a control diet for 15 months using the Geometric Framework, a novel method of nutritional analysis. Skin structure was associated with the ratio of dietary macronutrients eaten, not energy intake, and the nature of the effect differed between the sexes. In males, skin structure was primarily associated with protein intake, whereas in females carbohydrate intake was the primary correlate. In both sexes, the dermis and subcutaneous fat thicknesses were inversely proportional. Subcutaneous fat thickness varied positively with fat intake, due to enlarged adipocytes rather than increased adipocyte number. We therefore demonstrated clear interactions between skin structure and macronutrient intakes, with the associations being sex-specific and dependent on dietary macronutrient balance.
营养会影响皮肤结构；然而，尚未对能量和常量营养素（蛋白质、碳水化合物和脂肪）如何影响皮肤进行系统研究。我们使用一种新颖的营养分析方法——几何框架，评估了25种实验饮食和一种对照饮食喂养15个月的小鼠中常量营养素、能量摄入与皮肤结构之间的关联。皮肤结构与所摄入的膳食常量营养素比例相关，而非能量摄入，且这种影响的性质在两性之间存在差异。在雄性小鼠中，皮肤结构主要与蛋白质摄入相关，而在雌性小鼠中，碳水化合物摄入是主要的相关因素。在两性中，真皮和皮下脂肪厚度成反比。皮下脂肪厚度与脂肪摄入呈正相关，这是由于脂肪细胞增大而非脂肪细胞数量增加。因此，我们证明了皮肤结构与常量营养素摄入之间存在明显的相互作用，这种关联具有性别特异性且取决于膳食常量营养素平衡。
