Ribatti Domenico
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy, National Cancer Institute "Giovanni Paolo II", Bari, Italy.
Reprod Toxicol. 2017 Jun;70:97-101. doi: 10.1016/j.reprotox.2016.11.004. Epub 2016 Nov 8.
During avian development the mesodermal layers of the allantois and chorion fuse to form the chorioallantoic membrane (CAM). This structure rapidly expands generating a rich vascular network that provides an interface for gas and waste exchange. The CAM allows to study tissue grafts, tumor growth and metastasis, drugs delivery and toxicologic analysis, and angiogenic and anti-angiogenic molecules. The CAM is relatively simple, quick, and low-cost model that allows screening of a large number of pharmacological samples in a short time; does not require administrative procedures for obtaining ethics committee approval for animal experimentation. Moreover, being naturally immunodeficient, the chick embryo may receive transplantations from different tissues and species, without immune responses.
在禽类发育过程中，尿囊和绒毛膜的中胚层融合形成绒毛尿囊膜（CAM）。这种结构迅速扩展，形成丰富的血管网络，为气体和废物交换提供了一个界面。绒毛尿囊膜可用于研究组织移植、肿瘤生长与转移、药物递送和毒理学分析，以及血管生成和抗血管生成分子。绒毛尿囊膜是一种相对简单、快速且低成本的模型，能够在短时间内筛选大量药理样品；不需要为动物实验获得伦理委员会批准的行政程序。此外，鸡胚天然免疫缺陷，可接受来自不同组织和物种的移植，而不会产生免疫反应。
