Wan Zhenzhen, Hirche Christoph, Fricke Fabia, Dragu Adrian, Will Patrick A
Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Centre BG Klinik Ludwigshafen, Ludwigshafen, Germany,
Plastic Surgery and Hand Surgery, University Heidelberg, Heidelberg, Germany,
J Vasc Res. 2025;62(2):109-120. doi: 10.1159/000542875. Epub 2024 Dec 20.
The high incidence of vascular and lymphatic metastasis is closely associated with poor prognosis and mortality in cancer. Finding effective inhibitors to prevent pathological angiogenesis and lymphangiogenesis relies on appropriate in vivo models. The chick embryo chorioallantoic membrane (CAM) is formed by the fusion of the chorion and allantois during embryonic development.
In this context, we primarily summarize the changes in vascular and lymphatic vessel formation in tumors under the action of drugs using this model, providing a preclinical model basis for effective tumor inhibitors.
Due to natural immunological defects, chick embryos accept various tissue and species transplants without immune response. The CAM model has been widely used in studying angiogenesis, antiangiogenesis, tumor growth, tumor metastasis, and drug efficacy. This review describes the use of CAM assays as a valuable method for testing the in vivo effects of drugs on vascular and lymphatic vessel formation before further investigating the effects of drugs on tumor vessels and lymphatic vessels in animal models.
The high incidence of vascular and lymphatic metastasis is closely associated with poor prognosis and mortality in cancer. Finding effective inhibitors to prevent pathological angiogenesis and lymphangiogenesis relies on appropriate in vivo models. The chick embryo chorioallantoic membrane (CAM) is formed by the fusion of the chorion and allantois during embryonic development.
In this context, we primarily summarize the changes in vascular and lymphatic vessel formation in tumors under the action of drugs using this model, providing a preclinical model basis for effective tumor inhibitors.
Due to natural immunological defects, chick embryos accept various tissue and species transplants without immune response. The CAM model has been widely used in studying angiogenesis, antiangiogenesis, tumor growth, tumor metastasis, and drug efficacy. This review describes the use of CAM assays as a valuable method for testing the in vivo effects of drugs on vascular and lymphatic vessel formation before further investigating the effects of drugs on tumor vessels and lymphatic vessels in animal models.
血管和淋巴转移的高发生率与癌症的不良预后和死亡率密切相关。寻找有效的抑制剂来预防病理性血管生成和淋巴管生成依赖于合适的体内模型。鸡胚绒毛尿囊膜（CAM）是在胚胎发育过程中由绒毛膜和尿囊融合形成的。
在此背景下，我们主要总结了使用该模型时药物作用下肿瘤中血管和淋巴管形成的变化，为有效的肿瘤抑制剂提供临床前模型基础。
由于天然免疫缺陷，鸡胚接受各种组织和物种移植而无免疫反应。CAM模型已广泛用于研究血管生成、抗血管生成、肿瘤生长、肿瘤转移和药物疗效。本综述描述了在进一步研究药物对动物模型中肿瘤血管和淋巴管的影响之前，使用CAM试验作为测试药物对血管和淋巴管形成的体内作用的一种有价值的方法。
血管和淋巴转移的高发生率与癌症的不良预后和死亡率密切相关。寻找有效的抑制剂来预防病理性血管生成和淋巴管生成依赖于合适的体内模型。鸡胚绒毛尿囊膜（CAM）是在胚胎发育过程中由绒毛膜和尿囊融合形成的。
在此背景下，我们主要总结了使用该模型时药物作用下肿瘤中血管和淋巴管形成的变化，为有效的肿瘤抑制剂提供临床前模型基础。
由于天然免疫缺陷，鸡胚接受各种组织和物种移植而无免疫反应。CAM模型已广泛用于研究血管生成、抗血管生成、肿瘤生长、肿瘤转移和药物疗效。本综述描述了在进一步研究药物对动物模型中肿瘤血管和淋巴管的影响之前，使用CAM试验作为测试药物对血管和淋巴管形成的体内作用的一种有价值的方法。
