Stuchlik Ales, Radostová Dominika, Hatalova Hana, Vales Karel, Nekovarova Tereza, Koprivova Jana, Svoboda Jan, Horacek Jiri
Department of Neurophysiology of Memory, Institute of Physiology, Czech Academy of Sciences Prague, Czech Republic.
Department of Neurophysiology of Memory, Institute of Physiology, Czech Academy of SciencesPrague, Czech Republic; National Institute of Mental HealthKlecany, Czech Republic.
Front Behav Neurosci. 2016 Oct 26;10:209. doi: 10.3389/fnbeh.2016.00209. eCollection 2016.
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with 1-3% prevalence. OCD is characterized by recurrent thoughts (obsessions) and repetitive behaviors (compulsions). The pathophysiology of OCD remains unclear, stressing the importance of pre-clinical studies. The aim of this article is to critically review a proposed animal model of OCD that is characterized by the induction of compulsive checking and behavioral sensitization to the D2/D3 dopamine agonist quinpirole. Changes in this model have been reported at the level of brain structures, neurotransmitter systems and other neurophysiological aspects. In this review, we consider these alterations in relation to the clinical manifestations in OCD, with the aim to discuss and evaluate axes of validity of this model. Our analysis shows that some axes of validity of quinpirole sensitization model (QSM) are strongly supported by clinical findings, such as behavioral phenomenology or roles of brain structures. Evidence on predictive validity is contradictory and ambiguous. It is concluded that this model is useful in the context of searching for the underlying pathophysiological basis of the disorder because of the relatively strong biological similarities with OCD.
强迫症（OCD）是一种神经精神疾病，患病率为1%-3%。强迫症的特征是反复出现的想法（强迫观念）和重复行为（强迫行为）。强迫症的病理生理学尚不清楚，这凸显了临床前研究的重要性。本文的目的是批判性地综述一种提出的强迫症动物模型，该模型的特征是诱导强迫性检查以及对D2/D3多巴胺激动剂喹吡罗产生行为敏化。已报道该模型在脑结构、神经递质系统和其他神经生理学方面发生了变化。在本综述中，我们结合强迫症的临床表现来考虑这些改变，旨在讨论和评估该模型的有效性指标。我们的分析表明，喹吡罗敏化模型（QSM）的一些有效性指标得到了临床研究结果的有力支持，如行为现象学或脑结构的作用。关于预测有效性的证据相互矛盾且不明确。结论是，由于该模型与强迫症具有相对较强的生物学相似性，因此在寻找该疾病潜在病理生理基础的背景下是有用的。
