Eslami-Shahrbabaki Mahin, Fekrat Alireza, Mazhari Shahrzad
Assistant Professor, Neurology Research Center AND Department of Psychiatry, Afzalipour School of Medicine, Shahid Beheshti Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Resident, Department of Psychiatry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Addict Health. 2015 Winter-Spring;7(1-2):37-46.
The abuse of narcotic drugs and psychotropic substances such as amphetamines and ecstasy has had a growing trend. Tachycardia, increased blood pressure, hallucinations, panic attacks, and psychosis are the negative effects of methamphetamine abuse. The present study aimed to assess psychiatric disorders associated with methamphetamine-induced psychotic disorder.
This cross-sectional study was performed from October 2013 to March 2014 on 165 patients hospitalized at Shahid Beheshti Hospital in Kerman, Iran, and diagnosed with psychosis induced by methamphetamine abuse within the previous 6 months. Study subjects were selected via census method. Based on the exclusion criteria and due to the lack of cooperation of some patients, 121 patients were enrolled in the study. Research data were gathered using clinical interviews, the Yale-Brown obsessive compulsive scale (Y-BOCS), Hamilton anxiety scale (HAM-A) and Hamilton rating scale for depression (HRSD), Young mania rating scale (YMRS), substance dependence severity scale (SDSS), positive and negative syndrome scale (PANSS), and clinical global impression (CGI) scale. The data analysis was performed using SPSS software, descriptive statistics, and ANOVA.
Among the 121 patients of the sample group, 4 patients (3.3%) had anxiety, 58 patients (47.9%) depression, 30 patients (24.8%) obsessive-compulsive disorder (OCD), 20 patients (16.5%) bipolar mood disorder (BMD), 8 patients (6.6%) persistent psychotic symptoms, 85 patients (70.2%) personality disorder, and 36 patients (29.8%) had no personality disorders. The highest prevalence was related to borderline personality disorder (35.5%). However, 45 patients (37.2%) had no impairment associated with methamphetamine-induced psychosis.
It seems that there is comorbidity between psychiatric disorders, including mood disorders, especially depressive disorder, childhood history of attention deficit hyperactivity disorder (ADHD), bipolar disorder, and personality disorders such as borderline personality disorder, and antisocial personality disorders, and methamphetamine abuse.
麻醉药品和精神活性物质如苯丙胺和摇头丸的滥用呈上升趋势。心动过速、血压升高、幻觉、惊恐发作和精神病是甲基苯丙胺滥用的负面影响。本研究旨在评估与甲基苯丙胺所致精神障碍相关的精神疾病。
本横断面研究于2013年10月至2014年3月在伊朗克尔曼的沙希德·贝赫什提医院对165例住院患者进行，这些患者在过去6个月内被诊断为甲基苯丙胺滥用所致精神病。研究对象通过普查方法选取。基于排除标准且由于部分患者不合作，121例患者被纳入研究。研究数据通过临床访谈、耶鲁-布朗强迫量表（Y-BOCS）、汉密尔顿焦虑量表（HAM-A）、汉密尔顿抑郁量表（HRSD）、青年躁狂量表（YMRS）、物质依赖严重程度量表（SDSS）、阳性和阴性症状量表（PANSS）以及临床总体印象（CGI）量表收集。数据分析使用SPSS软件、描述性统计和方差分析。
在样本组的121例患者中，4例（3.3%）有焦虑症，58例（47.9%）有抑郁症，30例（24.8%）有强迫症（OCD），20例（16.5%）有双相情感障碍（BMD），8例（6.6%）有持续性精神病症状，85例（70.2%）有人格障碍，36例（29.8%）无人格障碍。患病率最高的是边缘型人格障碍（35.5%）。然而，45例（37.2%）患者没有与甲基苯丙胺所致精神病相关的损害。
似乎精神疾病之间存在共病，包括情绪障碍，尤其是抑郁症、注意力缺陷多动障碍（ADHD）童年史、双相情感障碍以及人格障碍如边缘型人格障碍和反社会人格障碍，与甲基苯丙胺滥用之间存在共病。
