（±）-钩藤碱A和B，来自钩藤的二聚异棘皮菌素型生物碱。
(±)-Uncarilins A and B, Dimeric Isoechinulin-Type Alkaloids from Uncaria rhynchophylla.
作者信息
Geng Chang-An, Huang Xiao-Yan, Ma Yun-Bao, Hou Bo, Li Tian-Ze, Zhang Xue-Mei, Chen Ji-Jun
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
出版信息
J Nat Prod. 2017 Apr 28;80(4):959-964. doi: 10.1021/acs.jnatprod.6b00938. Epub 2017 Feb 22.
(±)-Uncarilins A and B (1a/1b and 2a/2b), two pairs of unusual dimeric isoechinulin-type enantiomers with a symmetric four-membered core, were isolated from Uncaria rhynchophylla driven by LCMS-IT-TOF analyses. Their structures were elucidated by extensive 1D and 2D NMR spectra, X-ray diffraction, and ECD spectroscopic data. (-)-Uncarilin B (2a) showed activities on MT and MT receptors with agonistic rates of 11.26% and 52.44% at a concentration of 0.25 mM.
通过液相色谱-离子阱-飞行时间质谱（LCMS-IT-TOF）分析，从钩藤中分离得到了（±）-钩藤林A和B（1a/1b和2a/2b），这是两对具有对称四元核心的不寻常二聚异棘霉素型对映体。通过广泛的一维和二维核磁共振谱、X射线衍射和电子圆二色光谱数据阐明了它们的结构。（-）-钩藤林B（2a）对微管（MT）和MT受体具有活性，在浓度为0.25 mM时激动率分别为11.26%和52.44%。
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