Teri L, Borson S, Kiyak H A, Yamagishi M
Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle 98195.
J Am Geriatr Soc. 1989 Feb;37(2):109-16. doi: 10.1111/j.1532-5415.1989.tb05868.x.
The nature and severity of behavioral problems, and their relationship to cognitive and functional abilities, was investigated in 56 community-residing patients with Alzheimer's disease. Measures evaluated three domains of function: behavior, cognition and activities of daily living. Problems of cognitive functioning, such as memory loss, confusion, and disorientation were most prevalent, reported to occur in 84%, 82%, and 64% of the sample, respectively. Problems with activity and emotional distress were next, affecting 20 to 43% of the sample. The mean number of problems reported was 10 per patient. Twenty-two percent of caregivers reported a minimum of 15 problems occurring at least twice a week and no caregiver reported an absence of problems. Male patients were reported to have more behavioral difficulties. Level of behavioral disturbance was largely unrelated to cognitive or functional ability. Age was unrelated to cognitive or behavioral disturbance but significantly related to activities of daily living. Results indicated that behavioral problems are prevalent and pervasive in even moderately impaired community-residing Alzheimer disease patients, and that age may be more important than level of cognitive dysfunction in predicting difficulties with activities of daily living.
对56名居住在社区的阿尔茨海默病患者的行为问题的性质、严重程度及其与认知和功能能力的关系进行了调查。评估指标包括三个功能领域：行为、认知和日常生活活动。认知功能问题，如记忆力丧失、困惑和定向障碍最为普遍，据报告分别在84%、82%和64%的样本中出现。活动和情绪困扰问题其次，影响了20%至43%的样本。报告的问题平均数量为每位患者10个。22%的照料者报告至少有15个问题每周至少出现两次，没有照料者报告没有问题。据报告男性患者有更多的行为困难。行为障碍程度在很大程度上与认知或功能能力无关。年龄与认知或行为障碍无关，但与日常生活活动显著相关。结果表明，行为问题在即使是中度受损的社区居住的阿尔茨海默病患者中也很普遍且广泛存在，并且在预测日常生活活动困难方面，年龄可能比认知功能障碍程度更重要。
