Eyers Patrick A, Murphy James M
Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, Australia.
BMC Biol. 2016 Nov 11;14(1):98. doi: 10.1186/s12915-016-0322-x.
Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all major enzyme families. Their regulatory functions in signalling pathways are shedding new light on the non-catalytic functions of active enzymes, and are suggesting new ways to target cellular signalling mechanisms with drugs.
假酶是存在于所有主要酶家族中的酶的催化缺陷变体。它们在信号通路中的调节功能为活性酶的非催化功能带来了新的认识，并为用药物靶向细胞信号机制提出了新方法。
