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犬咬二氧化碳嗜纤维菌——猫狗咬伤后被低估的危险——文献综述

Capnocytophaga canimorsus – an underestimated danger after dog or cat bite – review of literature.

作者信息

Zajkowska Joanna, Król Monika, Falkowski Daniel, Syed Norina, Kamieńska Anna

机构信息

Medical University of Bialystok, Department of Infectious Diseases and Neuroinfections

出版信息

Przegl Epidemiol. 2016;70(2):289-295.

Abstract

Capnocytophaga canimorsus is a gram-negative, capnophilic rod constituting normal bacterial flora of the oral cavity of dogs and cats. It is also considered to be an etiological factor of infections in human that may lead to multiple complications, i.a. sepsis, endocarditis and meningitis. C. canimorsus poses a serious threat, especially to patients with asplenia, cirrhosis or alcohol abuse. In most cases, infection occurs after a dog bite. Isolation and identification of the bacteria from the biological material is difficult and often delayed because of slow growth of the bacteria on microbiological media. Gold standard for bacteriological identification of C. canimorsus is polymerase chain reaction method. Amoxicillin with clavulanic acid is considered the drug of choice used in prophylaxis of C. canimorsus infections. Based on the data available from the literature, the authors present the epidemiology, risk factors, clinical picture, diagnostic methods and treatment of the C. canimorsus infection.

摘要

犬咬二氧化碳嗜纤维菌是一种革兰氏阴性、嗜二氧化碳的杆菌,是犬猫口腔正常菌群的组成部分。它也被认为是人类感染的一个病因,可能导致多种并发症,如败血症、心内膜炎和脑膜炎。犬咬二氧化碳嗜纤维菌构成严重威胁,尤其是对无脾、肝硬化或酗酒患者。在大多数情况下,感染发生在被狗咬伤之后。由于该菌在微生物培养基上生长缓慢,从生物材料中分离和鉴定该菌很困难且往往会延迟。犬咬二氧化碳嗜纤维菌细菌学鉴定的金标准是聚合酶链反应方法。阿莫西林克拉维酸被认为是预防犬咬二氧化碳嗜纤维菌感染的首选药物。基于文献中的现有数据,作者介绍了犬咬二氧化碳嗜纤维菌感染的流行病学、危险因素、临床表现、诊断方法和治疗。

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