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水溶性鸡蛋膜增强了基于叶提取物的免疫激活特性。

Water-soluble egg membrane enhances the immunoactivating properties of an -based extract of leaves.

作者信息

Benson Kathleen F, Newman Robert A, Jensen Gitte S

机构信息

NIS Labs, Klamath Falls, OR.

Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston; Nerium Biotechnology Inc, San Antonio, TX, USA.

出版信息

Clin Cosmet Investig Dermatol. 2016 Nov 3;9:393-403. doi: 10.2147/CCID.S114471. eCollection 2016.

DOI:10.2147/CCID.S114471
PMID:27843333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5098409/
Abstract

OBJECTIVE

To evaluate a blend of two natural ingredients on immune parameters relevant for their current topical use and potential support of microcirculation in skin tissue.

MATERIALS AND METHODS

A blend (BL) of -based extract (NAE-8i, oleandrin-free) and hydrolyzed water-soluble egg membrane (WSEM) was applied to human whole-blood cultures for 24 hours, with each separate ingredient serving as a control. Immune-cell subsets were analyzed for expression levels of the activation markers CD69 and CD25. Culture supernatants were analyzed for cytokines, chemokines, and immunoregulating peptides.

RESULTS

BL increased CD69 expression on lymphocytes, monocytes, and CD3CD56 natural killer cells, and CD25 expression on natural killer cells. The number of CD69CD25 lymphocytes increased in cultures treated with BL and the separate ingredients. BL triggered production of multiple cytokines and chemokines, where CC chemokines MIP1α and MIP3α, as well as cytokines involved in wound healing - Groα, Groβ, ENA78, and fractalkine - reached levels manyfold above treatment with either NAE-8i or WSEM alone.

CONCLUSION

Data on BL showed that WSEM strongly enhanced NAE-8i's effects on immunoactivation in vitro. This has potential relevance for support of immunity in skin tissue, including antibacterial and antiviral defense mechanisms, wrinkle reduction, and wound care.

摘要

目的

评估两种天然成分的混合物对与其当前局部应用相关的免疫参数以及对皮肤组织微循环的潜在支持作用。

材料与方法

将基于提取物（不含夹竹桃苷的NAE - 8i）和水解水溶性鸡蛋膜（WSEM）的混合物（BL）应用于人类全血培养24小时，每种单独成分作为对照。分析免疫细胞亚群中活化标志物CD69和CD25的表达水平。分析培养上清液中的细胞因子、趋化因子和免疫调节肽。

结果

BL增加了淋巴细胞、单核细胞和CD3CD56自然杀伤细胞上CD69的表达，以及自然杀伤细胞上CD25的表达。在经BL和单独成分处理的培养物中，CD69CD25淋巴细胞的数量增加。BL引发了多种细胞因子和趋化因子的产生，其中CC趋化因子MIP1α和MIP3α以及参与伤口愈合的细胞因子——Groα、Groβ、ENA78和fractalkine——达到的水平比单独使用NAE - 8i或WSEM处理高出许多倍。

结论

关于BL的数据表明，WSEM在体外强烈增强了NAE - 8i对免疫激活的作用。这对于支持皮肤组织中的免疫，包括抗菌和抗病毒防御机制、减少皱纹和伤口护理具有潜在相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/caab2092703a/ccid-9-393Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/cca2f08d2d88/ccid-9-393Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/325191ff032d/ccid-9-393Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/afd8362a013a/ccid-9-393Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/7c56e4bcd8b0/ccid-9-393Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/bae72ca8c280/ccid-9-393Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/caab2092703a/ccid-9-393Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/cca2f08d2d88/ccid-9-393Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/325191ff032d/ccid-9-393Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/afd8362a013a/ccid-9-393Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/7c56e4bcd8b0/ccid-9-393Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/bae72ca8c280/ccid-9-393Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9e7/5098409/caab2092703a/ccid-9-393Fig6.jpg

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