Di Leo Milena, Leandro Gioacchino, Singh Satish K, Mariani Alberto, Bianco Margherita, Zuppardo Raffaella Alessia, Goni Elisabetta, Rogger Teresa Marzia, Di Mario Francesco, Guslandi Mario, De Cobelli Francesco, Del Maschio Alessandro, Testoni Pier Alberto, Cavestro Giulia Martina
From the *Gastrointestinal Endoscopy Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan; and †Gastroenterology Unit 1, Scientific Institute for Digestive Disease 'S. de Bellis' Hospital, Castellana Grotte, Italy ‡Institute for Digestive Liver Health, University College, London, United Kingdom; §Section of Gastroenterology Boston University School of Medicine Boston Medical Center, Boston, MA; ∥Department of Gastroenterology, Hepatology Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany; and ¶Department of Clinical Experimental Medicine, School of Medicine, University of Parma, Parma; and #Department of Radiology Center for Experimental Imaging, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Pancreas. 2017 Feb;46(2):225-229. doi: 10.1097/MPA.0000000000000737.
The aim of this study was to investigate the contribution of smoking and alcohol intake and pancreas divisum on the risk of developing chronic pancreatitis (CP).
Consecutive patients with CP who underwent secretin-enhanced magnetic resonance cholangiopancreatography were compared with consecutive patients without pancreatic disease who underwent secretin-enhanced magnetic resonance cholangiopancreatography for irritable bowel syndrome.
We enrolled 145 consecutive CP patients and 103 irritable bowel syndrome patients from 2010 to 2014. In a univariate analysis, statistically significant differences in sex, mean age, and the duration and amount of cigarette and alcohol use were found. Per a receiver operating characteristic curve analysis, thresholds for cigarette and alcohol consumption were, respectively, 5.5 cigarettes and 13.5 g daily. In a multivariate analysis, independent risk factors for CP were male sex (odds ratio [OR], 2.05), smoking more than 5.5 cigarettes per day (OR, 2.72), and drinking more than 13.5 g/d (OR, 6.35).
In an Italian population, we confirmed smoking and alcohol as cofactors in the development of CP. This study shows that alcohol intake and smoking habits are 2 of the most important risk factors for the development of CP.
本研究旨在探讨吸烟、饮酒及胰腺分裂对慢性胰腺炎（CP）发病风险的影响。
将连续接受促胰液素增强磁共振胰胆管造影的CP患者与因肠易激综合征连续接受促胰液素增强磁共振胰胆管造影的无胰腺疾病患者进行比较。
2010年至2014年，我们纳入了145例连续的CP患者和103例肠易激综合征患者。单因素分析发现，性别、平均年龄、吸烟和饮酒的持续时间及量存在统计学显著差异。根据受试者工作特征曲线分析，吸烟和饮酒的阈值分别为每天5.5支香烟和13.5克。多因素分析显示，CP的独立危险因素为男性（比值比[OR]，2.05）、每天吸烟超过5.5支（OR，2.72）以及每天饮酒超过13.5克（OR，6.35）。
在意大利人群中，我们证实吸烟和饮酒是CP发病的辅助因素。本研究表明，饮酒和吸烟习惯是CP发病的两个最重要危险因素。
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