Chand N, Eyre P
Res Commun Chem Pathol Pharmacol. 1978 Jun;20(3):435-48.
The anti-anaphylactic effects of four potential anti-allergic agents (DSCG: disodium cromoglycate, PRD-92-EA, M&B 22,948 and DECC: diethylcarbamazine citrate) were studied on cardiovascular responses of acute systemic anaphylaxis and chemical mediators of immediate hypersensitivity in chickens. Compounds M&B 22,948, PRD-92-EA, DSCG and DECC all inhibited cardiovascular manifestations of systemic anaphylaxis in domestic fowl. High doses of Compounds PRD-92 EA, M&B 22,948 and DECC also exhibited a nonspecific receptor blocking activity towards exogenously administered chemical mediators of anaphylaxis.
研究了四种潜在抗过敏剂（色甘酸二钠：DSCG、PRD - 92 - EA、M&B 22,948和枸橼酸乙胺嗪：DECC）对鸡急性全身性过敏反应的心血管反应以及速发型超敏反应化学介质的抗过敏作用。化合物M&B 22,948、PRD - 92 - EA、DSCG和DECC均能抑制家禽全身性过敏反应的心血管表现。高剂量的化合物PRD - 92 EA、M&B 22,948和DECC对外源性给予的过敏反应化学介质也表现出非特异性受体阻断活性。
