色甘酸二钠和硝茚二酮对大鼠速发型超敏反应的抑制作用。
Inhibition of immediate hypersensitivity reactions in the rat by disodium cromoglycate and nitroindanedione.
作者信息
Spicer B A, Ross J W, Smith H
出版信息
Clin Exp Immunol. 1975 Sep;21(3):419-29.
Abstract
A nitroindanedione (BRL 10833) and disodium cromoglycate (DSCG) showed similar activities as inhibitors of IgE-mediated passive cutaneous anaphylaxis (PCA) and passive peritoneal anaphylaxis (PPA) reactions in the rat. BRL 10833 was more active than DSCG when given parenterally and unlike DSCG it inhibited the PCA reaction in the rat after oral administration. In the PCA test both compounds produced a state of refractoriness both to themselves and to each other. Isoprenaline also inhibited the PCA reaction but its activity was not reduced when the rats were refractory to DSCG.
摘要
一种硝基茚二酮（BRL 10833）和色甘酸二钠（DSCG）在大鼠中作为IgE介导的被动皮肤过敏反应（PCA）和被动腹膜过敏反应（PPA）的抑制剂表现出相似的活性。当经肠胃外给药时，BRL 10833比DSCG更具活性，并且与DSCG不同的是，口服给药后它能抑制大鼠中的PCA反应。在PCA试验中，这两种化合物对自身和彼此都产生了不应状态。异丙肾上腺素也能抑制PCA反应，但当大鼠对DSCG产生不应性时，其活性并未降低。
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