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酒精与血压:吕贝克血压研究结果

Alcohol and blood pressure: results from the Luebeck Blood Pressure Study.

作者信息

Keil U, Chambless L, Remmers A

机构信息

Department of Epidemiology, GSF-Medis Institute, Neuherberg bei München, Federal Republic of Germany.

出版信息

Prev Med. 1989 Jan;18(1):1-10. doi: 10.1016/0091-7435(89)90049-2.

Abstract

Data from the Luebeck Blood Pressure Study, a cross-sectional study on a random sample (n = 3,100) of the 30- to 69-year-old population of Luebeck, were analyzed with regard to alcohol consumption and blood pressure. Putative confounders such as obesity, smoking, physical activity, and educational attainment were controlled for by multiple regression analyses. Luebeck men who consumed more than 40 g of alcohol per day revealed 5-6 mm Hg higher mean systolic and 4-5 mm Hg higher mean diastolic blood pressure values. A J-shaped relationship between alcohol consumption and systolic blood pressure was seen in Luebeck men. According to our calculations, about 7% of hypertension among Luebeck men is due to alcohol consumption of greater than or equal to 40 g/day. Among women, strong interactions between age and alcohol consumption were found, therefore two age groups, 30-44 and 45-69 years, were analyzed separately. In the younger age group the alcohol-blood pressure relationship was not pronounced. In the older age group a strong interaction between alcohol consumption and smoking was found. For female smokers steep increases in the adjusted mean diastolic (5.2 mm Hg) and systolic (9.6 mm Hg) blood pressure values were seen for the alcohol consumption category greater than or equal to 20 g/day. For female nonsmokers a flat curve was seen with regard to mean diastolic and systolic blood pressure values. The data from the Munich Blood Pressure Study show a very similar relationship between alcohol consumption and mean systolic and diastolic blood pressure values.

摘要

吕贝克血压研究是一项针对吕贝克30至69岁随机抽样人群(n = 3100)的横断面研究,对其饮酒情况和血压数据进行了分析。通过多元回归分析控制了肥胖、吸烟、体育活动和教育程度等潜在混杂因素。吕贝克男性每天饮酒超过40克者,其平均收缩压高5 - 6毫米汞柱,平均舒张压高4 - 5毫米汞柱。吕贝克男性饮酒量与收缩压之间呈J形关系。根据我们的计算,吕贝克男性中约7%的高血压病例归因于每日饮酒量大于或等于40克。在女性中,发现年龄与饮酒之间存在强烈交互作用,因此将两个年龄组,即30 - 44岁和45 - 69岁,分别进行分析。在较年轻年龄组中,饮酒与血压的关系不明显。在较年长年龄组中,发现饮酒与吸烟之间存在强烈交互作用。对于女性吸烟者,每日饮酒量大于或等于20克的类别,其调整后的平均舒张压(5.2毫米汞柱)和收缩压(9.6毫米汞柱)值急剧上升。对于女性非吸烟者,平均舒张压和收缩压值呈平缓曲线。慕尼黑血压研究的数据显示,饮酒量与平均收缩压和舒张压值之间存在非常相似的关系。

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