Kim Ha-Ryong, Hwang Gi-Wook, Naganuma Akira, Chung Kyu-Hyuck
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan.
J Toxicol Sci. 2016;41(6):711-717. doi: 10.2131/jts.41.711.
Exposure to humidifier disinfectants was identified in 2011 as the potential cause of an outbreak of lung disease in Korea. It is estimated that over 8 million people have been exposed to humidifier disinfectants-chemicals added to the water used in humidifiers to prevent the growth of microorganisms-since their commercial introduction. The primary component of humidifier disinfectant products involved was polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial agent. Lesions observed in the lungs of patients were similar to those observed in laboratory animals exposed to PHMG-P. In this review, we outline the physicochemical and toxicological properties of PHMG-P, and introduce a putative mechanism for its lung toxicity based in large part on research findings to date.
2011年，接触加湿器消毒剂被认定为韩国肺部疾病爆发的潜在原因。据估计，自加湿器消毒剂商业化推出以来，已有超过800万人接触过这种添加到加湿器用水中以防止微生物生长的化学物质。涉事加湿器消毒剂产品的主要成分是聚六亚甲基胍磷酸盐（PHMG-P），一种胍基抗菌剂。在患者肺部观察到的病变与在接触PHMG-P的实验动物中观察到的病变相似。在这篇综述中，我们概述了PHMG-P的物理化学和毒理学特性，并主要基于迄今为止的研究结果介绍了一种关于其肺部毒性的假定机制。
