金（I）催化醛对含6-芳基-1,5-烯炔的环亚丙基的加成反应。
Gold(i)-catalyzed addition of aldehydes to cyclopropylidene bearing 6-aryl-1,5-enynes.
作者信息
Roselli Christina A, Gagné Michel R
机构信息
Department of Chemistry. University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
出版信息
Org Biomol Chem. 2016 Nov 29;14(47):11261-11265. doi: 10.1039/c6ob02128j.
Abstract
A diastereoselective, gold-catalyzed cascading cycloisomerization of alkylidene cyclopropane bearing 1,5-enynes that terminates in a cyclo-addition of aldehydes has been developed. This diastereoselective reaction provides convergent access to novel polycyclic molecular structures (18 examples), and tolerates a diverse scope of aldehydes. Mechanistic studies reveal that the catalytic cycle rests at a digold off-cycle intermediate, one of which was isolated.
摘要
已开发出一种非对映选择性的、金催化的含1,5-烯炔的亚烷基环丙烷的级联环异构化反应，该反应以醛的环加成反应结束。这种非对映选择性反应为新型多环分子结构（18个实例）提供了汇聚式合成途径，并且能耐受多种醛。机理研究表明，催化循环停留在一种双金非循环中间体上，其中一种中间体已被分离出来。
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