幽门螺杆菌对原住民和太平洋岛民男性胃癌高发的影响：一项出生队列研究估计
The contribution of Helicobacter pylori to excess gastric cancer in Indigenous and Pacific men: a birth cohort estimate.
作者信息
Teng Andrea M, Blakely Tony, Baker Michael G, Sarfati Diana
机构信息
Department of Public Health, University of Otago, PO Box 7343, Wellington, New Zealand.
出版信息
Gastric Cancer. 2017 Jul;20(4):752-755. doi: 10.1007/s10120-016-0671-8. Epub 2016 Nov 16.
BACKGROUND
The reasons for higher gastric cancer incidence rates in indigenous populations are debated.
METHODS
We quantify the role of Helicobacter pylori in excess gastric cancer incidence in Māori and Pacific men in New Zealand. Age-standardized gastric cancer rate ratios for 1981-2004 were calculated in Māori and Pacific men compared with European/other men born in 1926-1940 and in 1941-1955. Rate ratios were then compared with those restricted to H. pylori prevalent populations.
RESULTS
H. pylori contributed substantially to excess gastric cancer incidence in Māori men (50%, 61%) and Pacific men (71%, 82%) in both cohorts.
CONCLUSIONS
Policy should focus on reducing the acquisition and prevalence of H. pylori infection in these populations.
背景
原住民胃癌发病率较高的原因存在争议。
方法
我们量化了幽门螺杆菌在新西兰毛利人和太平洋岛民男性胃癌发病率过高方面所起的作用。计算了1981 - 2004年毛利人和太平洋岛民男性与1926 - 1940年及1941 - 1955年出生的欧洲/其他男性相比的年龄标准化胃癌发病率比值。然后将这些发病率比值与仅限于幽门螺杆菌流行人群的发病率比值进行比较。
结果
在两个队列中，幽门螺杆菌在毛利男性（50%，61%）和太平洋岛民男性（71%，82%）胃癌发病率过高方面起了很大作用。
结论
政策应侧重于降低这些人群中幽门螺杆菌感染的获得率和流行率。
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