Immunomodulating properties of the N-(1-deoxy-D-fructos-lyl) derivative of amphotericin B in mice.

Immunomodulating properties of the N-(1-deoxy-D-fructos-lyl) derivative of Amphotericin B (N-Fru-AmB) was investigated in vitro on T and B mouse lymphocytes and compared to that of the original AmB molecule. Results indicate that N-Fru-AmB is a potent polyclonal B cell activator capable of inducing B lymphocytes to proliferate and to differentiate into Ig secreting cells in absence of any additional signal. N-Fru-AmB is also mitogenic for a fraction of peripheral T lymphocytes. Together, the results suggest a potential interest of such derivatives in the treatment of mycosal infections in immunodeficient patients.