Ye Li-Juan, Bian Hui, Fan Yao-Dong, Wang Zheng-Bo, Yu Hua-Lin, Ma Yuan-Ye, Chen Feng
Department of Pathology, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China; Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China; Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Department of Physiology, Kunming Medical University, Kunming, Yunnan Province, China.
Neural Regen Res. 2016 Sep;11(9):1464-1470. doi: 10.4103/1673-5374.191221.
Rhesus monkey neural stem cells are capable of differentiating into neurons and glial cells. Therefore, neural stem cell transplantation can be used to promote functional recovery of the nervous system. Rhesus monkey neural stem cells (1 × 10 cells/μL) were injected into bilateral hippocampi of rats with hippocampal lesions. Confocal laser scanning microscopy demonstrated that green fluorescent protein-labeled transplanted cells survived and grew well. Transplanted cells were detected at the lesion site, but also in the nerve fiber-rich region of the cerebral cortex and corpus callosum. Some transplanted cells differentiated into neurons and glial cells clustering along the ventricular wall, and integrated into the recipient brain. Behavioral tests revealed that spatial learning and memory ability improved, indicating that rhesus monkey neural stem cells noticeably improve spatial learning and memory abilities in rats with hippocampal lesions.
恒河猴神经干细胞能够分化为神经元和神经胶质细胞。因此，神经干细胞移植可用于促进神经系统的功能恢复。将恒河猴神经干细胞（1×10个细胞/微升）注射到海马损伤大鼠的双侧海马中。共聚焦激光扫描显微镜显示，绿色荧光蛋白标记的移植细胞存活且生长良好。在损伤部位检测到移植细胞，在大脑皮质和胼胝体富含神经纤维的区域也检测到移植细胞。一些移植细胞分化为神经元和神经胶质细胞，沿脑室壁聚集，并整合到受体大脑中。行为测试显示空间学习和记忆能力得到改善，表明恒河猴神经干细胞显著提高了海马损伤大鼠的空间学习和记忆能力。
