Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus, Denmark.
Nanoscale. 2016 Dec 1;8(47):19510-19522. doi: 10.1039/c6nr07807a.
Therapeutic cell mimicry is an approach in nanomedicine aiming at substituting for missing or lost cellular functions employing nature-inspired concepts. Pioneered decades ago, only now is this technology empowered with the arsenal of nanotechnological tools and ready to provide radically new solutions such as assembling synthetic organelles and artificial cells. One of these tools is droplet microfluidics (D-μF), which provides the flexibility to generate cargo-loaded particles with tunable size and shape in a fast and reliable manner, an essential requirement in cell mimicry. This minireview aims at outlining the developments in D-μF from the past four years focusing on the assembly of nanoparticles, Janus-shaped and other non-spherical particles as well as their loading with biological payloads.
治疗性细胞模拟是一种纳米医学方法，旨在利用受自然启发的概念来替代缺失或丧失的细胞功能。该技术在几十年前就已经开创，直到现在才拥有纳米技术工具的武器库，并准备提供全新的解决方案，例如组装合成细胞器和人工细胞。其中一种工具是液滴微流控（D-μF），它提供了以快速可靠的方式生成具有可调节大小和形状的载药颗粒的灵活性，这是细胞模拟的基本要求。本篇综述旨在概述过去四年中 D-μF 的发展情况，重点介绍了纳米粒子、Janus 形状和其他非球形粒子的组装及其生物有效载荷的装载。
