Harville Emily W, Juonala Markus, Viikari Jorma S A, Kähönen Mika, Raitakari Olli T
a Department of Epidemiology , Tulane University School of Public Health , New Orleans , Louisiana , USA.
b Department of Medicine, University of Turku and Division of Medicine , Turku University Hospital , Turku , Finland.
Hypertens Pregnancy. 2017 Feb;36(1):53-58. doi: 10.1080/10641955.2016.1237643. Epub 2016 Nov 18.
To examine the relationship between pre-pregnancy indicators of cardiovascular risk and pregnancy complications and outcomes.
Data from 359 female participants in the Cardiovascular Risk in Young Finns Study were linked with the national birth registry. Flow-mediated dilatation (FMD; maximum change in the left brachial artery diameter after rest and hyperemia); carotid intima-media thickness (IMT); Young's elastic modulus (YEM); and carotid artery distensibility (Cdist) at the visit prior to the pregnancy were examined as predictors of hypertensive disorders, birthweight, and gestational age using multivariable linear regression with adjustment for confounders (age, BMI, smoking, and socioeconomic status).
No relations were seen between FMD, IMT, or the stiffness indices, and hypertensive disorders. Higher pre-pregnancy FMD was associated with lower gestational age, while increased Cdist was associated with reduced birthweight-for-gestational-age.
Some cardiovascular ultrasound measures of pre-pregnancy may predict pregnancy complications, but the association is likely to be small.
研究孕前心血管风险指标与妊娠并发症及结局之间的关系。
对参与芬兰年轻人心血管风险研究的359名女性参与者的数据与国家出生登记处的数据进行关联分析。在怀孕前的访视中，检测血流介导的血管舒张功能（FMD；静息和充血后左肱动脉直径的最大变化）、颈动脉内膜中层厚度（IMT）、杨氏弹性模量（YEM）以及颈动脉扩张性（Cdist），并采用多变量线性回归分析，对混杂因素（年龄、体重指数、吸烟和社会经济状况）进行校正，以评估这些指标作为高血压疾病、出生体重和孕周的预测因素。
未发现FMD、IMT或硬度指数与高血压疾病之间存在关联。孕前较高水平的FMD与较低的孕周相关，而Cdist升高与小于胎龄儿出生体重降低相关。
一些孕前心血管超声测量指标可能预测妊娠并发症，但这种关联可能较小。
