Igase Michiya, Ohara Maya, Igase Keiji, Kato Takeaki, Okada Yoko, Ochi Masayuki, Tabara Yasuharu, Kohara Katsuhiko, Ohyagi Yasumasa
Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Japan.
Department of Neurosurgery, Washokai Sadamoto Hospital, Japan.
J Alzheimers Dis. 2017;55(4):1481-1487. doi: 10.3233/JAD-160917.
Accumulation of advanced glycation endproducts (AGEs) is thought to be involved in the pathogenesis of dementia, especially Alzheimer's disease. Tissue AGE accumulation can be estimated using the relative simple noninvasive measurement of skin autofluorescence (SAF), a method based on the fluorescent properties of some AGEs. However, possible involvement of tissue AGE accumulation in mild cognitive impairment (MCI) has not been fully investigated.
We investigated whether tissue AGE accumulation estimated by SAF is associated with mild cognitive impairment.
We analyzed 226 community-dwelling subjects. In addition to several atherosclerosis-related clinical parameters, MCI screening test, assessment of brain atrophy, and SAF were performed on people aged > 40 years. MCI was assessed using the Japanese version of the MCI screening method. Atrophy of the brain was assessed by examining the temporal horn area (THA) by brain MRI.
SAF was significantly higher in participants with MCI than in those with normal cognitive function (2.56±0.55 versus 2.10±0.41; p < 0.001). Logistic regression analyses with adjustment for confounding factors including age and THA showed that high SAF > 2.27 was significantly related to the presence of MCI (odds, 6.402; 95% CI, 1.590-25.773, p = 0.009).
We found an association between SAF and MCI, which was independent of brain atrophy, in healthy subjects.
晚期糖基化终末产物（AGEs）的积累被认为与痴呆症，尤其是阿尔茨海默病的发病机制有关。组织AGE积累可以通过相对简单的非侵入性皮肤自发荧光（SAF）测量来估计，这是一种基于某些AGEs荧光特性的方法。然而，组织AGE积累在轻度认知障碍（MCI）中的可能作用尚未得到充分研究。
我们研究了通过SAF估计的组织AGE积累是否与轻度认知障碍有关。
我们分析了226名社区居住受试者。除了几个与动脉粥样硬化相关的临床参数外，还对年龄大于40岁的人群进行了MCI筛查测试、脑萎缩评估和SAF测量。使用日本版的MCI筛查方法评估MCI。通过脑部MRI检查颞角区域（THA）来评估脑萎缩。
MCI参与者的SAF显著高于认知功能正常者（2.56±0.55对2.10±0.41；p<0.001）。对包括年龄和THA在内的混杂因素进行调整的逻辑回归分析表明，SAF>2.27与MCI的存在显著相关（比值，6.402；95%CI，1.590 - 25.773，p = 0.009）。
我们发现健康受试者中SAF与MCI之间存在关联，且这种关联独立于脑萎缩。
