Glycation, Nutrition and Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Eur J Nutr. 2018 Sep;57(6):2209-2216. doi: 10.1007/s00394-017-1495-y. Epub 2017 Jun 27.
Advanced glycation endproducts (AGEs) are produced endogenously and also enter the body during the consumption of AGEs present in heat-processed food. It is unknown whether AGEs of dietary origin accumulate within the body of healthy individuals. AGEs can deposit within skin tissue long-term by crosslinking extracellular matrix proteins. The fluorescent nature of many AGEs enables their detection within the skin by non-invasively measuring skin autofluorescence (SAF). This study aimed to identify habitual dietary and lifestyle behaviours cross-sectionally associated with SAF in an adult population sample.
251 Healthy adult volunteers completed validated food frequency and physical activity questionnaires. Waist circumference, BMI, blood pressure and blood glucose was also measured. SAF was measured using an AGE Reader.
Significant positive correlations were found between SAF and chronological age (r = 0.63, P < 0.001), waist circumference (r = 0.28, P < 0.01), body weight (r = 0.24, P < 0.05), BMI (r = 0.23, P < 0.05) and consumption of meat and meat products (r = 0.22, P < 0.05). A negative correlation was found between SAF and cereal consumption (r = -0.21, P < 0.05). Cigarette smokers also had a significantly higher SAF than non-smokers (2.4 vs 2.0 U, P < 0.05). Regression analysis identified age, cigarette smoking, waist circumference and intake of meat products as significant predictors of SAF. The regression model explained 48% of the variation in SAF.
Age, cigarette smoking, waist circumference and dietary consumption of meat/meat products were positively associated with SAF in this sample. Further research is required to determine whether frequent consumption of foods containing large quantities of dietary AGEs contribute to pathological disease processes in healthy individuals.
晚期糖基化终产物（AGEs）在体内内源性产生，也可通过摄入热加工食品中的 AGEs 进入体内。目前尚不清楚健康个体的体内是否会积累饮食来源的 AGEs。AGEs 可以通过交联细胞外基质蛋白在皮肤组织中长期沉积。许多 AGEs 的荧光特性使其能够通过非侵入性测量皮肤自体荧光（SAF）在皮肤中被检测到。本研究旨在确定习惯性饮食和生活方式行为与成年人样本中 SAF 的横断面相关性。
251 名健康成年志愿者完成了经过验证的食物频率和体力活动问卷。还测量了腰围、BMI、血压和血糖。使用 AGE 阅读器测量 SAF。
SAF 与年龄（r=0.63，P<0.001）、腰围（r=0.28，P<0.01）、体重（r=0.24，P<0.05）、BMI（r=0.23，P<0.05）和肉和肉产品的摄入量呈显著正相关（r=0.22，P<0.05）。SAF 与谷物摄入量呈负相关（r=-0.21，P<0.05）。吸烟者的 SAF 明显高于非吸烟者（2.4 与 2.0 U，P<0.05）。回归分析确定年龄、吸烟、腰围和肉类产品摄入量是 SAF 的显著预测因子。回归模型解释了 SAF 变化的 48%。
在本样本中，年龄、吸烟、腰围和肉类/肉类产品的饮食摄入量与 SAF 呈正相关。需要进一步研究以确定频繁食用含有大量饮食 AGEs 的食物是否会导致健康个体的病理性疾病过程。
