State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China.
Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Adv Healthc Mater. 2016 Dec;5(24):3165-3172. doi: 10.1002/adhm.201601058. Epub 2016 Nov 17.
Plasmonic nanostructures are of potential in acting as a type of optical agents for cancer photothermal therapy. To effectively function as photothermal therapy agents, plasmonic nanostructures are strongly desired to have good biocompatibility and high photothermal conversion efficiencies. In this study, poly(diallyldimethylammonium chloride)-coated porous Pt nanoparticles are synthesized for photothermal therapy. The Pt nanoparticles possess broadband near-infrared light absorption in the range from 650 to 1200 nm, therefore allowing for selecting different laser wavelengths for photothermal therapy. The as-prepared Pt nanoparticles exhibit remarkable photothermal conversion efficiencies under 809 and 980 nm laser irradiation. In vitro studies indicate that the Pt nanoparticles display good biocompatibility and high cellular uptake efficiencies through an endocytosis pathway. Photothermal heating using 808 nm laser irradiation (>7.0 W cm , 3 min) leads to notable cytotoxic effect, and more than 70% of cells are photothermally ablated after 3 min irradiation at 8.4 W cm . Furthermore, simultaneous application of photothermal therapy synergistically enhances the cytotoxicity of an anti-cancer drug doxorubicin. Therefore, the porous Pt nanoparticles have great potential as an attractive photothermal agent for cancer therapy.
等离子体纳米结构在作为癌症光热治疗的光学试剂方面具有潜力。为了有效地作为光热治疗试剂发挥作用，强烈希望等离子体纳米结构具有良好的生物相容性和高光热转换效率。在这项研究中，合成了聚（二烯丙基二甲基氯化铵）包覆的多孔 Pt 纳米颗粒用于光热治疗。Pt 纳米颗粒在 650 至 1200nm 的近红外光范围内具有宽带光吸收，因此可以选择不同的激光波长进行光热治疗。在 809nm 和 980nm 激光辐照下，所制备的 Pt 纳米颗粒表现出显著的光热转换效率。体外研究表明，Pt 纳米颗粒通过内吞作用途径表现出良好的生物相容性和高细胞摄取效率。使用 808nm 激光辐照（>7.0Wcm^-2，3min）进行光热加热会导致明显的细胞毒性效应，并且在 8.4Wcm^-2 下照射 3 分钟后，超过 70%的细胞被光热消融。此外，光热治疗的同时应用协同增强了抗癌药物阿霉素的细胞毒性。因此，多孔 Pt 纳米颗粒作为癌症治疗的一种有吸引力的光热试剂具有很大的潜力。
