Wang Xingxin, Li Xuhao, Dong Tiantian, Yu Wenyan, Jia Zhixia, Hou Yi, Yang Jiguo, Liu Yuanxiang
College of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, China.
Traditional Chinese Medicine External Treatment Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Int J Surg. 2024 Dec 1;110(12):7962-7983. doi: 10.1097/JS9.0000000000001799.
Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) in cancer tissue. The lack of specific biomarkers makes the diagnosis and prognosis of TNBC challenging.
A comprehensive literature review and bibliometric analysis was performed using CiteSpace, VOSviewer and Scimago Graphica.
TNBC biomarker research has been growing rapidly in recent years, reflecting the enormous academic interest in TNBC biomarker research. A total of 127 journals published relevant studies and 1749 authors were involved in the field, with developed countries such as the United States, France, and the United Kingdom contributing greatly to the field. Collaborative network analysis found that the research in this field has not yet formed good communication and interaction, and the partnership should be strengthened in the future in order to promote the in-depth development of TNBC biomarker research. A comprehensive analysis of keywords and co-cited literature, etc. found that TNBC biomarker research mainly focuses on immune checkpoint markers, microenvironment-related markers, circulating tumor DNA, metabolic markers, genomics markers and so on. These research hotspots will help to better understand the molecular characteristics and biological processes of TNBC, and provide more accurate biomarkers for its diagnosis, treatment and prognosis.
The bibliometric analysis highlighted global trends and key directions in TNBC biomarker research. Future developments in TNBC biomarker research are likely to be in the direction of multi-omics integration, meticulous study of the microenvironment, targeted therapeutic biomarkers, application of liquid biopsy, application of machine learning and artificial intelligence, and individualized therapeutic strategies. Young scholars should learn and collaborate across disciplines, pay attention to new technologies and methods, improve their data analysis skills, and continue to follow up on the latest research trends in order to meet the challenges and opportunities in the field of TNBC biomarkers.
三阴性乳腺癌（TNBC）被定义为癌组织中雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER-2）均为阴性的乳腺癌。缺乏特异性生物标志物使得TNBC的诊断和预后具有挑战性。
使用CiteSpace、VOSviewer和Scimago Graphica进行了全面的文献综述和文献计量分析。
近年来TNBC生物标志物研究发展迅速，反映出学术界对TNBC生物标志物研究的极大兴趣。共有127种期刊发表了相关研究，该领域涉及1749位作者，美国、法国和英国等发达国家对该领域贡献巨大。合作网络分析发现，该领域的研究尚未形成良好的交流与互动，未来应加强合作关系，以促进TNBC生物标志物研究的深入发展。对关键词和共被引文献等进行综合分析发现，TNBC生物标志物研究主要集中在免疫检查点标志物、微环境相关标志物、循环肿瘤DNA、代谢标志物、基因组学标志物等方面。这些研究热点将有助于更好地了解TNBC的分子特征和生物学过程，并为其诊断、治疗和预后提供更准确的生物标志物。
文献计量分析突出了TNBC生物标志物研究的全球趋势和关键方向。TNBC生物标志物研究未来的发展可能朝着多组学整合、对微环境的精细研究、靶向治疗生物标志物、液体活检的应用、机器学习和人工智能的应用以及个体化治疗策略的方向发展。青年学者应跨学科学习与合作，关注新技术和方法，提高数据分析能力，并持续跟进最新研究趋势，以应对TNBC生物标志物领域的挑战与机遇。
