Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA.
Allergy. 2017 Mar;72(3):366-372. doi: 10.1111/all.13080. Epub 2016 Dec 15.
Cutaneous lymphocyte-associated antigen (CLA ) T cells are specialized for skin homing and represent the main T-cell population in atopic dermatitis (AD) lesions. CLA is expressed on the surface of circulating CD45RO memory T cells and most skin-infiltrating T cells. Mechanistic studies and thus treatment advancements are limited by the need of large number of skin biopsies. Circulating CLA T cells may be a reliable surrogate marker of the inflammatory events occurring in the skin, and thus, the evaluation of CLA T cells in the blood may eliminate the need for skin biopsies. Preliminary work in AD has established that disease-associated T-cell abnormalities can be approached by either a study of skin lesions or activated CLA T-cell subsets in peripheral blood. Future studies in adults and children, across different skin disorders, correlating blood and skin phenotypes and determining skin-homing T-cell functional properties are needed to establish whether CLA memory subsets can be used as biomarkers and a substitute for skin biopsies. This review summarizes the latest advancements reached on circulating CLA in AD and the great potential they harbor in understanding AD mechanisms.
皮肤淋巴细胞相关抗原（CLA）T 细胞是专门用于皮肤归巢的，并且是特应性皮炎（AD）病变中主要的 T 细胞群体。CLA 表达在循环 CD45RO 记忆 T 细胞和大多数皮肤浸润 T 细胞的表面。由于需要大量的皮肤活检，因此机制研究和治疗进展受到限制。循环 CLA T 细胞可能是皮肤发生炎症事件的可靠替代标志物，因此，血液中 CLA T 细胞的评估可能无需进行皮肤活检。AD 的初步研究已经证实，通过研究皮肤病变或外周血中活化的 CLA T 细胞亚群，可以研究与疾病相关的 T 细胞异常。未来需要在不同皮肤疾病的成人和儿童中进行研究，将血液和皮肤表型相关联，并确定归巢 T 细胞的功能特性，以确定 CLA 记忆细胞亚群是否可用作生物标志物和皮肤活检的替代物。本综述总结了在 AD 中循环 CLA 方面取得的最新进展，以及它们在理解 AD 机制方面的巨大潜力。
