O'Kelly Fardod, DeCotiis Keara, Zu'bi Fadi, Farhat Walid A, Koyle Martin A
Division of Urology, The Hospital for Sick Children, Toronto, ON, M5G1X8, Canada.
Pediatr Surg Int. 2020 Feb;36(2):247-253. doi: 10.1007/s00383-019-04600-3. Epub 2019 Nov 20.
Hypospadias is a common congenital male disorder, with much research focusing on prenatal androgen exposure as a causative factor. Whilst digit length ratios were apparent in sexual dimorphism since the nineteenth century, their role in hypospadias remains unknown. The objective of our study was to determine the correlation between digit length (2D:4D) ratio, hypospadias severity, and anogenital distance.
Pre-pubertal boys (<3 years old) seen intra/postoperatively following hypospadias repair (June 2018-January 2019 inc.) were included. These were age-matched to non-hypospadias controls. Anthropomorphic measurements of digit lengths, penile/glans width, and anogenital distance were measured using digital calipers.
Data measurements were collected for 105 boys with hypospadias (60 distal; 45 proximal) and 55 controls. There were significant differences in 2D:4D ratios in each hand (p < 0.001), as well as individual digits (p < 0.001), and a reduced anogenital distance (p < 0.001), when comparing the proximal group with distal or control groups. There were no significant differences in glans width, or between term- and preterm births.
This study is the first to demonstrate increased 2D:4D ratios with proximal hypospadias, which also correlate with a shortened anogenital distance. This may provide a non-invasive, potentially antenatal, anthropomorphic measurement, as an indirect indicator of aberrant urogenital development.
尿道下裂是一种常见的先天性男性疾病，许多研究聚焦于产前雄激素暴露作为致病因素。自19世纪以来，手指长度比例在性别二态性中就很明显，但其在尿道下裂中的作用仍不清楚。我们研究的目的是确定手指长度（2D:4D）比例、尿道下裂严重程度和肛门生殖器距离之间的相关性。
纳入2018年6月至2019年1月期间接受尿道下裂修复术的青春期前男孩（<3岁），这些男孩在术前/术后就诊。将他们与非尿道下裂对照组进行年龄匹配。使用数字卡尺测量手指长度、阴茎/龟头宽度和肛门生殖器距离的人体测量数据。
收集了105例尿道下裂男孩（60例远端型；45例近端型）和55例对照组的数据测量值。将近端型组与远端型组或对照组进行比较时，每只手的2D:4D比例（p < 0.001）、各个手指（p < 0.001）以及肛门生殖器距离均有显著差异（p < 0.001）。龟头宽度以及足月儿与早产儿之间没有显著差异。
本研究首次证明近端型尿道下裂的2D:4D比例增加，这也与缩短的肛门生殖器距离相关。这可能提供一种非侵入性的、潜在的产前人体测量方法，作为泌尿生殖系统发育异常的间接指标。
