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Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway.

作者信息

Kong Pengyu, Chen Guanghua, Jiang Anlong, Wang Yufu, Song Chengchao, Zhuang Jinpeng, Xi Chunyang, Wang Guangxi, Ji Ye, Yan Jinglong

机构信息

Department of Orthopedics Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

出版信息

Oncotarget. 2016 Dec 13;7(50):83720-83726. doi: 10.18632/oncotarget.13360.

DOI:10.18632/oncotarget.13360
PMID:27863411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5347798/
Abstract

Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1β. Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1β-stimulated chondrocytes. Sesamin also inhibited IL-1β-induced phosphorylation of NF-κB p65 and IκBα. Meanwhile, sesamin was found to up-regulate the expression of Nrf2 and HO-1. However, Nrf2 siRNA reversed the anti-inflammatory effects of sesamin. In conclusion, our results suggested that sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes by activating Nrf2 signaling pathway.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/b3cef2264a64/oncotarget-07-83720-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/5cf771eed14e/oncotarget-07-83720-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/5281294b295f/oncotarget-07-83720-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/1b5a2a65d1c4/oncotarget-07-83720-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/df933c785854/oncotarget-07-83720-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/4a4246a5dea5/oncotarget-07-83720-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/b3cef2264a64/oncotarget-07-83720-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/5cf771eed14e/oncotarget-07-83720-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/5281294b295f/oncotarget-07-83720-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/1b5a2a65d1c4/oncotarget-07-83720-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/df933c785854/oncotarget-07-83720-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/4a4246a5dea5/oncotarget-07-83720-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4c4/5347798/b3cef2264a64/oncotarget-07-83720-g006.jpg

相似文献

[1]
Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway.

Oncotarget. 2016-12-13

[2]
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Biomed Pharmacother. 2018-8-27

[3]
Anti-Inflammatory Effects of Licochalcone A on IL-1β-Stimulated Human Osteoarthritis Chondrocytes.

Inflammation. 2017-12

[4]
Thymoquinone Inhibits IL-1β-Induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing NF-κB and MAPKs Signaling Pathway.

Inflammation. 2015-12

[5]
Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation.

Eur J Pharmacol. 2016-6-5

[6]
Sauchinone inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocytes to attenuate osteoarthritis via Nrf2/HO-1 and NF-κB pathways.

Int Immunopharmacol. 2018-7-20

[7]
Morin Exhibits Anti-Inflammatory Effects on IL-1β-Stimulated Human Osteoarthritis Chondrocytes by Activating the Nrf2 Signaling Pathway.

Cell Physiol Biochem. 2018

[8]
Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways.

Int Immunopharmacol. 2019-7-13

[9]
Anti-inflammatory effects of farrerol on IL-1β-stimulated human osteoarthritis chondrocytes.

Eur J Pharmacol. 2015-10-5

[10]
Scoparone prevents IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-κB pathway.

Biomed Pharmacother. 2018-7-18

引用本文的文献

[1]
The Nrf2/HO-1 pathway participates in the antiapoptotic and anti-inflammatory effects of platelet-rich plasma in the treatment of osteoarthritis.

Immun Inflamm Dis. 2024-6

[2]
A randomized double-blind active-controlled clinical trial on the efficacy of topical basil () oil in knee osteoarthritis.

Front Pharmacol. 2024-5-6

[3]
The promising antioxidant effects of lignans: Nrf2 activation comes into view.

Naunyn Schmiedebergs Arch Pharmacol. 2024-9

[4]
Anti-Osteoarthritis Mechanism of the Nrf2 Signaling Pathway.

Biomedicines. 2023-11-29

[5]
Anti-COVID-19, Anti-Inflammatory, and Anti-Osteoarthritis Activities of Sesamin from L.

Bioengineering (Basel). 2023-10-30

[6]
Sesamin: A Promising Therapeutic Agent for Ameliorating Symptoms of Diabetes.

Molecules. 2023-10-25

[7]
Effects of sesame ( L.) and bioactive compounds (sesamin and sesamolin) on inflammation and atherosclerosis: A review.

Food Sci Nutr. 2023-5-22

[8]
Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation.

Heliyon. 2023-1-20

[9]
Human papillomavirus is an important risk factor for esophageal carcinoma in a Chinese population.

J Cancer Res Clin Oncol. 2023-7

[10]
Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis.

Antioxidants (Basel). 2022-8-30

本文引用的文献

[1]
Sesamin inhibits lipopolysaccharide-induced inflammation and extracellular matrix catabolism in rat intervertebral disc.

Connect Tissue Res. 2016-9

[2]
Morin suppresses inflammatory cytokine expression by downregulation of nuclear factor-κB and mitogen-activated protein kinase (MAPK) signaling pathways in lipopolysaccharide-stimulated primary bovine mammary epithelial cells.

J Dairy Sci. 2016-4

[3]
Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts.

Free Radic Biol Med. 2015-12

[4]
Sesamin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibition of TLR4 Signaling Pathways.

Inflammation. 2016-2

[5]
Nrf2--A regulator of keratinocyte redox signaling.

Free Radic Biol Med. 2015-11

[6]
The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.

Free Radic Biol Med. 2015-4-14

[7]
Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice.

Biochem Biophys Res Commun. 2015-5-29

[8]
Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells.

Oncol Rep. 2015-6

[9]
Metabolic triggered inflammation in osteoarthritis.

Osteoarthritis Cartilage. 2015-1

[10]
Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte.

Int Immunopharmacol. 2013-7-6

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