Qiang Li, Yuan Jiang, Shouyin Jiang, Yulin Li, Libing Jiang, Jian-An Wang
Emergency Department, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Inflammation. 2016 Feb;39(1):467-472. doi: 10.1007/s10753-015-0270-6.
Recent studies suggested that TLR4 signaling pathways played an important role in the development of LPS-induced acute lung injury (ALI). Sesamin, a sesame lignan exacted from sesame seeds, has been shown to exhibit significant anti-inflammatory activity. The purpose of this study was to investigate the anti-inflammatory effects of sesamin on LPS-induced ALI in mice. Mice ALI model was induced by intratracheal instillation of LPS. Sesamin was given 1 h after LPS challenge. Our results showed that sesamin inhibited LPS-induced lung pathological change, edema, and myeloperoxidase (MPO) activity. Sesamin suppressed LPS-induced inflammatory cytokines TNF-α, IL-6, and IL-1β production. Furthermore, sesamin inhibited LPS-induced TLR4 expression and NF-κB activation. In conclusion, the results of this study indicated that sesamin protected against LPS-induced ALI by inhibition of TLR4 signaling pathways.
最近的研究表明，Toll样受体4（TLR4）信号通路在脂多糖（LPS）诱导的急性肺损伤（ALI）的发生发展中起重要作用。芝麻素是从芝麻种子中提取的一种芝麻木脂素，已被证明具有显著的抗炎活性。本研究的目的是探讨芝麻素对LPS诱导的小鼠ALI的抗炎作用。通过气管内滴注LPS诱导小鼠ALI模型。在LPS攻击后1小时给予芝麻素。我们的结果表明，芝麻素可抑制LPS诱导的肺病理变化、水肿和髓过氧化物酶（MPO）活性。芝麻素可抑制LPS诱导的炎性细胞因子肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-1β（IL-1β）的产生。此外，芝麻素可抑制LPS诱导的TLR4表达和核因子-κB（NF-κB）激活。总之，本研究结果表明，芝麻素通过抑制TLR4信号通路对LPS诱导的ALI具有保护作用。
