精准医学与正电子发射断层显像/计算机断层扫描：挑战与实施
Precision Medicine and PET/Computed Tomography: Challenges and Implementation.
作者信息
Subramaniam Rathan M
机构信息
Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Biomedical Engineering, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.
出版信息
PET Clin. 2017 Jan;12(1):1-5. doi: 10.1016/j.cpet.2016.08.010. Epub 2016 Sep 30.
Precision Medicine is about selecting the right therapy for the right patient, at the right time, specific to the molecular targets expressed by disease or tumors, in the context of patient's environment and lifestyle. Some of the challenges for delivery of precision medicine in oncology include biomarkers for patient selection for enrichment-precision diagnostics, mapping out tumor heterogeneity that contributes to therapy failures, and early therapy assessment to identify resistance to therapies. PET/computed tomography offers solutions in these important areas of challenges and facilitates implementation of precision medicine.
精准医学是指在患者的环境和生活方式背景下，针对疾病或肿瘤所表达的分子靶点，在正确的时间为正确的患者选择正确的治疗方法。肿瘤学中精准医学的一些挑战包括用于富集精准诊断的患者选择生物标志物、确定导致治疗失败的肿瘤异质性，以及早期治疗评估以识别对治疗的耐药性。正电子发射断层显像/计算机断层扫描（PET/CT）在这些重要的挑战领域提供了解决方案，并促进了精准医学的实施。
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