分子成像与精准医学：肿瘤学中的正电子发射断层显像/计算机断层扫描及治疗反应评估
Molecular Imaging and Precision Medicine: PET/Computed Tomography and Therapy Response Assessment in Oncology.
作者信息
Sheikhbahaei Sara, Mena Esther, Pattanayak Puskar, Taghipour Mehdi, Solnes Lilja B, Subramaniam Rathan M
机构信息
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA.
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA; Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Biomedical Engineering, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
出版信息
PET Clin. 2017 Jan;12(1):105-118. doi: 10.1016/j.cpet.2016.08.002. Epub 2016 Oct 5.
A variety of methods have been developed to assess tumor response to therapy. Standardized qualitative criteria based on 18F-fluoro-deoxyglucose PET/computed tomography have been proposed to evaluate the treatment effectiveness in specific cancers and these allow more accurate therapy response assessment and survival prognostication. Multiple studies have addressed the utility of the volumetric PET biomarkers as prognostic indicators but there is no consensus about the preferred segmentation methodology for these metrics. Heterogeneous intratumoral uptake was proposed as a novel PET metric for therapy response assessment. PET imaging techniques will be used to study the biological behavior of cancers during therapy.
已经开发了多种方法来评估肿瘤对治疗的反应。基于18F-氟脱氧葡萄糖PET/计算机断层扫描的标准化定性标准已被提出，用于评估特定癌症的治疗效果，这些标准可以更准确地评估治疗反应和生存预后。多项研究探讨了体积PET生物标志物作为预后指标的效用，但对于这些指标的首选分割方法尚无共识。肿瘤内摄取异质性被提出作为一种用于治疗反应评估的新型PET指标。PET成像技术将用于研究癌症在治疗过程中的生物学行为。
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