Tamminen Jakke, Lambon Ralph Matthew A, Lewis Penelope A
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, UK; Department of Psychology, Royal Holloway, University of London, UK.
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, UK.
Neurobiol Learn Mem. 2017 Jan;137:77-82. doi: 10.1016/j.nlm.2016.11.012. Epub 2016 Nov 15.
Recent memories are spontaneously reactivated during sleep, leading to their gradual strengthening. Whether reactivation also mediates the integration of new memories with existing knowledge is unknown. We used targeted memory reactivation (TMR) during slow-wave sleep (SWS) to selectively cue reactivation of newly learned spoken words. While integration of new words into their phonological neighbourhood was observed in both cued and uncued words after sleep, TMR-triggered integration was predicted by the time spent in rapid eye movement (REM) sleep. These data support complementary roles for SWS and REM in memory consolidation.
近期记忆在睡眠期间会自发地重新激活，从而使其逐渐得到强化。重新激活是否也介导新记忆与现有知识的整合尚不清楚。我们在慢波睡眠（SWS）期间使用靶向记忆重新激活（TMR）来选择性地提示新学口语单词的重新激活。虽然睡眠后在有提示和无提示的单词中均观察到新单词融入其语音邻域，但TMR引发的整合可由快速眼动（REM）睡眠中的时长预测。这些数据支持SWS和REM在记忆巩固中发挥互补作用。
