关节血流量对炎症性关节炎比氧合血红蛋白、脱氧血红蛋白和氧饱和度更敏感。
Joint blood flow is more sensitive to inflammatory arthritis than oxyhemoglobin, deoxyhemoglobin, and oxygen saturation.
作者信息
Rajaram Ajay, Ioussoufovitch Seva, Morrison Laura B, St Lawrence Keith, Lee Ting-Yim, Bureau Yves, Diop Mamadou
机构信息
Imaging Program, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada; Department of Medical Biophysics, Western University, London, Ontario, N6A 5C1, Canada.
Imaging Program, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada; Department of Medical Biophysics, Western University, London, Ontario, N6A 5C1, Canada; Imaging Program, Robarts Research Institute, 100 Perth Drive, London, Ontario N6A 5K8, Canada.
出版信息
Biomed Opt Express. 2016 Sep 1;7(10):3843-3854. doi: 10.1364/BOE.7.003843. eCollection 2016 Oct 1.
Joint hypoxia plays a central role in the progression and perpetuation of rheumatoid arthritis (RA). Thus, optical techniques that can measure surrogate markers of hypoxia such as blood flow, oxyhemoglobin, deoxyhemoglobin, and oxygen saturation are being developed to monitor RA. The purpose of the current study was to compare the sensitivity of these physiological parameters to arthritis. Experiments were conducted in a rabbit model of RA and the results revealed that joint blood flow was the most sensitive to arthritis and could detect a statistically significant difference (p<0.05, power = 0.8) between inflamed and healthy joints with a sample size of only four subjects. Considering that this a technique, the high sensitivity to arthritis suggests that joint perfusion has the potential to become a potent tool for monitoring disease progression and treatment response in RA.
关节缺氧在类风湿性关节炎（RA）的进展和持续发展中起着核心作用。因此，正在开发能够测量缺氧替代标志物（如血流、氧合血红蛋白、脱氧血红蛋白和氧饱和度）的光学技术来监测RA。本研究的目的是比较这些生理参数对关节炎的敏感性。在RA兔模型中进行了实验，结果显示关节血流对关节炎最为敏感，仅用四个受试者的样本量就能检测出炎症关节和健康关节之间具有统计学意义的差异（p<0.05，检验效能=0.8）。考虑到这是一种技术，对关节炎的高敏感性表明关节灌注有可能成为监测RA疾病进展和治疗反应的有力工具。
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