Yang Ping, Cai Linghu, Zhang Guan, Bian Zhiqun, Han Gaofeng
Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, 400038, PR China.
Cadet Brigade, Third Military Medical University, Chongqing, 400038, PR China.
J Neurosci Res. 2017 Aug;95(8):1574-1581. doi: 10.1002/jnr.23991. Epub 2016 Nov 21.
It is well known that neurogenesis is not the only concern for the fully functional recovery after brain or spinal cord injury, as it has been shed light on the critical role of angiogenesis in improving neurological functional recovery. Angiogenesis and neurogenesis coordinately interact with each other in the developing and adult brain, during which they may respond to similar mediators and receptors, in which they share a common posttranscriptional regulator: the miR-17-92 cluster. The miR-17-92 cluster was initially described as an oncogene and was later demonstrated to drive key physiological and pathological responses during development and diseases respectively. It has been reported that the miR-17-92 cluster regulates both neurogenesis and angiogenesis. The miR-17-92 cluster modulates neural progenitor cells proliferation not only during development but also during neurological disorders such as stroke. It has also been shown that the endothelial miR-17-92 cluster regulates angiogenesis during embryonic stage and adulthood. In this review, we have discussed the actions of the miR-17-92 cluster in neuronal and vascular plasticity, and its potential as a novel therapeutic strategy for CNS injury. © 2016 Wiley Periodicals, Inc.
众所周知，神经发生并非脑或脊髓损伤后功能完全恢复的唯一关注点，因为血管生成在改善神经功能恢复方面的关键作用已受到关注。在发育中的大脑和成年大脑中，血管生成和神经发生相互协调作用，在此过程中它们可能对相似的介质和受体产生反应，其中它们共享一个共同的转录后调节因子：miR-17-92簇。miR-17-92簇最初被描述为一种癌基因，后来分别被证明在发育和疾病过程中驱动关键的生理和病理反应。据报道，miR-17-92簇调节神经发生和血管生成。miR-17-92簇不仅在发育过程中，而且在诸如中风等神经疾病期间调节神经祖细胞的增殖。研究还表明，内皮miR-17-92簇在胚胎期和成年期调节血管生成。在本综述中，我们讨论了miR-17-92簇在神经元和血管可塑性中的作用，及其作为中枢神经系统损伤新治疗策略的潜力。© 2016威利期刊公司
