Vargas Alexander, Saad Eduardo, Dimech George Santiago, Santos Roselene Hans, Sivini Maria Auxiliadora Vieira Caldas, Albuquerque Luciana Carolina, Lima Patricia Michelly Santos, Barreto Idalacy de Carvalho, Andrade Michelly Evangelista de, Estima Nathalie Mendes, Carvalho Patrícia Ismael de, Azevedo Rayane Souza de Andrade, Vasconcelos Rita de Cássia de Oliveira, Assunção Romildo Siqueira, Frutuoso Lívia Carla Vinhal, Carmo Greice Madeleine Ikeda do, Souza Priscila Bochi de, Wada Marcelo Yoshito, Oliveira Wanderson Kleber de, Henriques Cláudio Maierovitch Pessanha, Percio Jadher
Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília-DF, Brasil.
Secretaria Estadual de Saúde de Pernambuco, Recife-PE, Brasil.
Epidemiol Serv Saude. 2016 Oct-Dec;25(4):691-700. doi: 10.5123/S1679-49742016000400003. Epub 2016 Sep 26.
to describe the first cases of microcephaly possibly related to Zika virus in live born babies reported in the Metropolitan Region of Recife, Pernambuco State, Brazil.
this was a descriptive case series study (cases reported between August 1st and October 31st 2015), using medical record data and data from a questionnaire answered by the mothers of the babies.
40 microcephaly cases were confirmed, distributed in eight municipalities within the Metropolitan Region, with Recife itself having the highest concentration of cases (n=12); median head circumference was 29 cm, median chest girth was 31 cm and median weight was 2,628 grams; 21/25 cases had brain calcification, ventriculomegaly or lissencephaly; 27 of the 40 mothers reported rash during pregnancy, 20 in the first trimester and 7 in the second trimester, as well as itching, headache, myalgia and absence of fever.
the majority of the cases bore the characteristics of congenital infection; the clinical condition of the majority of mothers suggested Zika virus infection during pregnancy.
描述巴西伯南布哥州累西腓大都市区报告的活产婴儿中首批可能与寨卡病毒有关的小头畸形病例。
这是一项描述性病例系列研究（2015年8月1日至10月31日期间报告的病例），使用病历数据以及婴儿母亲填写的问卷数据。
确诊40例小头畸形病例，分布在大都市区内的8个市，累西腓市病例最为集中（n = 12）；头围中位数为29厘米，胸围中位数为31厘米，体重中位数为2628克；25例中有21例出现脑钙化、脑室扩大或无脑回畸形；40位母亲中有27位报告孕期出现皮疹，其中20例在孕早期，7例在孕中期，同时伴有瘙痒、头痛、肌痛且无发热症状。
大多数病例具有先天性感染的特征；大多数母亲的临床症状表明孕期感染了寨卡病毒。
