2015年巴西塞尔希培州小头畸形活产儿的临床流行病学描述
Clinical-epidemiological description of live births with microcephaly in the state of Sergipe, Brazil, 2015.
作者信息
Cabral Cibelle Mendes, Nóbrega Martha Elizabeth Brasil da, Leite Priscila Leal E, Souza Mércia Simone Feitosa de, Teixeira Daniela Cabral Pizzi, Cavalcante Taíse Ferreira, Lima Raulinna Gomes de Souza, Tavares Lúcia Maria Sayde de Azevedo, Souza Priscila Bochi de, Saad Eduardo
机构信息
Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília-DF, Brasil.
Secretaria de Estado da Saúde de Sergipe, Diretoria de Vigilância em Saúde, Aracaju-SE, Brasil.
出版信息
Epidemiol Serv Saude. 2017 Apr-Jun;26(2):245-254. doi: 10.5123/S1679-49742017000200002.
OBJECTIVE
to describe the clinical and epidemiological characteristics of microcephaly cases in live births in Sergipe, Brazil, and to calculate the prevalence in its municipalities.
METHODS
this is a descriptive study on live births from September 1st to November 30th, 2015, with data from medical records and interviews with mothers.
RESULTS
83 cases of microcephaly were confirmed, with three deaths; prevalence in the 26 municipalities with confirmed cases ranged from 18 to 185/10,000 live births; the median of head circumference was 31 cm (range: 22.5-33.0); agenesis of corpus callosum (26/43), lissencephaly (12/43), absence of midline (10/43) and ventriculomegaly (8/43) were observed in the transfontanellar ultrasound; 40 mothers reported rash in pregnancy, 23 in the first trimester, with pruritus, arthralgia and headache; seven were positive for infections potentially causing malformations.
CONCLUSION
there was a high occurrence of cases of microcephaly, and reports of signs and symptoms compatible with Zika virus infection during pregnancy.
目的
描述巴西塞尔希培州活产儿中小头畸形病例的临床和流行病学特征，并计算其各市的患病率。
方法
这是一项针对2015年9月1日至11月30日活产儿的描述性研究，数据来自病历及对母亲的访谈。
结果
确诊83例小头畸形病例，3例死亡；26个有确诊病例的市的患病率在每10000例活产儿中为18至185例；头围中位数为31厘米（范围：22.5 - 33.0）；经囟门超声检查发现胼胝体发育不全（26/43）、无脑回畸形（12/43）、中线缺失（10/43）和脑室扩大（8/43）；40名母亲报告孕期出疹，23名在孕早期出疹，伴有瘙痒、关节痛和头痛；7名母亲感染可能导致畸形的病毒呈阳性。
结论
小头畸形病例发生率较高，且有孕期与寨卡病毒感染相符的体征和症状报告。
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