巴西皮奥伊州的小头畸形：2015 - 2016年寨卡病毒流行期间的描述性研究
Microcephaly in Piauí, Brazil: descriptive study during the Zika virus epidemic, 2015-2016.
作者信息
Ribeiro Igor Gonçalves, Andrade Marcia Regina de, Silva Janaína de Moraes, Silva Zenira Martins, Costa Maria Amélia de Oliveira, Vieira Marcelo Adriano da Cunha E Silva, Batista Francisca Miriane de Araújo, Guimarães Herlon, Wada Marcelo Yoshito, Saad Eduardo
机构信息
Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília, DF, Brasil.
Secretaria de Estado da Saúde do Piauí, Superintendência de Atenção Integral à Saúde, Teresina, PI, Brasil.
出版信息
Epidemiol Serv Saude. 2018 Feb 1;27(1):e20163692. doi: 10.5123/S1679-49742018000100002.
OBJECTIVE
to describe the occurrence and characteristics of microcephaly cases in Piauí, Brazil, during an epidemic of Zika virus infection in 2015-2016.
METHODS
descriptive study using data of live births from January/2015 to January/2016, obtained from the Information System on Live Births (Sinasc), the Public Health Events Registry (RESP) and the active search for medical records; mothers and live births were tested for dengue, chikungunya, and Zika, besides syphilis, toxoplasmosis, rubella, cytomegalovirus, and herpes (STORCH).
RESULTS
of the 75 microcephaly cases, 34 were related to congenital infectious process; microcephaly prevalence was of 13.6/10 thousand live births; imaging exams confirmed that 34 live births presented calcifications, 23 had cerebral atrophies, 14 had lissencephaly, 12 had ventriculomegaly and 6 had dysgenesis; none tested positive for STORCH, dengue or chikungunya; 1 was IgM positive for Zika.
CONCLUSION
there was an outbreak of microcephaly in Piauí, possibly related to infection during pregnancy Zika virus.
目的
描述2015 - 2016年巴西皮奥伊州寨卡病毒感染流行期间小头畸形病例的发生情况及特征。
方法
采用描述性研究，使用2015年1月至2016年1月活产数据，这些数据来自活产信息系统（Sinasc）、公共卫生事件登记处（RESP）以及对病历的主动搜索；除梅毒、弓形虫病、风疹、巨细胞病毒和疱疹（STORCH）外，还对母亲和活产儿进行登革热、基孔肯雅热和寨卡病毒检测。
结果
75例小头畸形病例中，34例与先天性感染过程有关；小头畸形患病率为13.6/万活产儿；影像学检查证实，34例活产儿有钙化，23例有脑萎缩，14例有平滑脑，12例有脑室扩大，6例有发育异常；STORCH、登革热或基孔肯雅热检测均为阴性；1例寨卡病毒IgM阳性。
结论
皮奥伊州爆发了小头畸形，可能与孕期感染寨卡病毒有关。
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