Sheykholeslam Z, Houpt M
Community Dent Oral Epidemiol. 1978 Jul;6(4):181-4. doi: 10.1111/j.1600-0528.1978.tb01146.x.
The clinical effectiveness of Delton fissure sealant was studied in 205 children, ages 6--10 years (mean age 71/2). 993 children in grades 1, 2, 3 and 4 were screened and subjects were selected if there was evidence of previous dental caries in the mouth, and a pair of contralateral maxillary or mandibular first permanent molar teeth were free of caries. Two pedodontists independently examined the children in a mobile van equipped with two operatories, and each applied sealants to approximately half of the subjects. After 11 months, in 186 subjects there were 10 sealants partially lost, five experimental teeth carious or filled and 53 control teeth carious or filled. After 24 months, in 175 subjects there were four sealants completely lost, 12 sealants partially lost, 11 experimental teeth carious or filled and 89 control teeth carious or filled. Consequently, sealant retention was 92% after 11 months and 85% after 24 months. Percent effectiveness in caries reduction was 90% after 11 months and 88% after 2 years.
对205名6至10岁（平均年龄7.5岁）的儿童进行了德尔顿窝沟封闭剂的临床疗效研究。对993名一、二、三、四年级的儿童进行了筛查，若口腔中有既往龋齿证据，且一对对侧上颌或下颌第一恒磨牙无龋齿，则选取这些儿童作为研究对象。两名儿童牙医在一辆配备了两个诊疗室的移动面包车上对儿童进行独立检查，每人给大约一半的研究对象应用封闭剂。11个月后，186名研究对象中有10个封闭剂部分脱落，5颗试验牙龋坏或已充填，53颗对照牙龋坏或已充填。24个月后，175名研究对象中有4个封闭剂完全脱落，12个封闭剂部分脱落，11颗试验牙龋坏或已充填，89颗对照牙龋坏或已充填。因此，11个月后封闭剂保留率为92%，24个月后为85%。11个月后龋齿减少的有效率为90%，2年后为88%。
