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性别对神经系统的影响:迈向临床进展的基本步骤。

Sex/gender influences on the nervous system: Basic steps toward clinical progress.

作者信息

Brooks Claudette Elise, Clayton Janine Austin

机构信息

Office of Research on Women's Health (ORWH), Office of the Director, National Institutes of Health, Bethesda, Maryland.

出版信息

J Neurosci Res. 2017 Jan 2;95(1-2):14-16. doi: 10.1002/jnr.23902.

DOI:10.1002/jnr.23902
PMID:27870446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5123599/
Abstract

A Commentary highlighting the progress that sex-based data and research have made in neuroscience and the complexities that research has revealed thus far. Basic and preclinical neuroscientific research that considers sex as a biological variable will continue to build on the foundation of knowledge that has been started by multiple predecessors. The expansion of knowledge in preclinical neuroscience that integrates the study of both sexes will have a significant role in informing clinical trial design. We applaud the efforts of the editors and authors who have contributed to this issue. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

摘要

一篇评论文章,着重介绍了基于性别的数据和研究在神经科学领域取得的进展,以及迄今为止研究所揭示的复杂性。将性别视为生物学变量的基础和临床前神经科学研究将继续建立在众多前辈所奠定的知识基础之上。整合两性研究的临床前神经科学知识扩展,将在为临床试验设计提供信息方面发挥重要作用。我们赞赏为本期刊物撰稿的编辑和作者所付出的努力。2016年发表。本文为美国政府作品,在美国属于公共领域。

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本文引用的文献

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Single-nucleotide polymorphism rs948854 in human galanin gene and multiple sclerosis: a gender-specific risk factor.人类甘丙肽基因单核苷酸多态性rs948854与多发性硬化症:一种性别特异性风险因素。
J Neurosci Res. 2017 Jan 2;95(1-2):644-651. doi: 10.1002/jnr.23887.
2
The immune system as a novel regulator of sex differences in brain and behavioral development.免疫系统作为大脑和行为发育中性别差异的新型调节因子。
J Neurosci Res. 2017 Jan 2;95(1-2):447-461. doi: 10.1002/jnr.23821.
3
Sex differences in animal models of decision making.决策动物模型中的性别差异。
J Neurosci Res. 2017 Jan 2;95(1-2):260-269. doi: 10.1002/jnr.23810.
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Sex differences in stroke therapies.中风治疗中的性别差异。
J Neurosci Res. 2017 Jan 2;95(1-2):681-691. doi: 10.1002/jnr.23855.
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Sex differences in nonhuman primate behavioral development.非人灵长类动物行为发育中的性别差异。
J Neurosci Res. 2017 Jan 2;95(1-2):213-221. doi: 10.1002/jnr.23862.
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(Putative) sex differences in neuroimmune modulation of memory.记忆神经免疫调节中的(假定)性别差异。
J Neurosci Res. 2017 Jan 2;95(1-2):472-486. doi: 10.1002/jnr.23921.
7
Sex differences in neuroimmunity and pain.神经免疫与疼痛中的性别差异。
J Neurosci Res. 2017 Jan 2;95(1-2):500-508. doi: 10.1002/jnr.23831.
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Studying both sexes: a guiding principle for biomedicine.研究两性:生物医学的一项指导原则。
FASEB J. 2016 Feb;30(2):519-24. doi: 10.1096/fj.15-279554. Epub 2015 Oct 29.
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Insufficient sex description of cells supplied by commercial vendors.商业供应商提供的细胞的性别描述不足。
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Sex bias exists in basic science and translational surgical research.基础科学和转化性外科研究中存在性别偏见。
Surgery. 2014 Sep;156(3):508-16. doi: 10.1016/j.surg.2014.07.001.