Cook N R, Evans D A, Scherr P A, Speizer F E, Vedal S, Branch L G, Huntley J C, Hennekens C H, Taylor J O
Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Am J Epidemiol. 1989 Jul;130(1):66-78. doi: 10.1093/oxfordjournals.aje.a115324.
A population survey was conducted in 1982-1983 among 3,812 persons aged 65 years and older residing in East Boston, Massachusetts, a geographically defined urban community. Three measurements of peak expiratory flow rate were obtained by using calibrated mini-Wright meters. Peak expiratory flow rate was strongly related to age, sex, smoking, and years smoked. After adjustment for these factors, low peak expiratory flow rate was associated with chronic respiratory symptoms (cough, wheeze, shortness of breath, exertional dyspnea, orthopnea, and paroxysmal nocturnal dyspnea; p less than 0.0001) and with certain cardiovascular variables (history of stroke, p = 0.0014; angina, p = 0.05; and high pulse rate, p = 0.004). No significant associations were found with history of myocardial infarction or systolic and diastolic blood pressures. Peak expiratory flow rate was positively related to education (p less than 0.0001) and income (p less than 0.0001). Peak expiratory flow rate also was strongly related (p less than 0.0001) to measures of functional ability and physical activity, self-assessment of health, and simple measures of cognitive function. The correlations of peak expiratory flow rate with pulmonary symptoms and other indices of chronic disease raise the possibility that peak expiratory flow rate will predict mortality in an elderly population.
1982年至1983年，在马萨诸塞州东波士顿一个地理界定明确的城市社区，对3812名65岁及以上的居民进行了一项人口调查。使用校准后的小型赖特流量计进行了三次呼气峰值流速测量。呼气峰值流速与年龄、性别、吸烟情况和吸烟年限密切相关。在对这些因素进行调整后，低呼气峰值流速与慢性呼吸道症状（咳嗽、喘息、气短、运动性呼吸困难、端坐呼吸和阵发性夜间呼吸困难；p<0.0001）以及某些心血管变量（中风病史，p = 0.0014；心绞痛，p = 0.05；高脉搏率，p = 0.004）相关。未发现与心肌梗死病史或收缩压和舒张压有显著关联。呼气峰值流速与教育程度（p<0.0001）和收入（p<0.0001）呈正相关。呼气峰值流速还与功能能力和身体活动指标、健康自我评估以及认知功能简单指标密切相关（p<0.0001）。呼气峰值流速与肺部症状及其他慢性病指标之间的相关性增加了呼气峰值流速可预测老年人群死亡率的可能性。
