Primhak R A, Biggins J D, Tsanakas J N, Hatzimichael A, Milner R D, Karpouzas J G
Br J Dis Chest. 1984 Jan;78(1):26-35.
Standing height and peak expiratory flow rate (PEFR) were measured in 339 British schoolchildren aged 7-16 years. Enquiry was made into a past history of wheeze or atopy, a family history of asthma or atopy, or a cold within the preceding 2 weeks. A strong correlation was found between PEFR and height, expressed by the equation PEFR = 5.640 Ht - 472.5 (r = 0.89). Neither a recent cold nor a positive personal or family history of wheeze or atopy had any significant effect on the regression equation. Sex was also unimportant. Further examination of the data revealed that age had an effect on peak expiratory flow rate independent of height. The effect of age was linear in girls and curvilinear in boys. Five hundred and sixty-nine Greek schoolchildren were also studied and similar age effects were found on the regression of peak expiratory flow rate on height. The implication of these findings is that any population study of peak expiratory flow rates in children should ensure a normal age distribution at each height interval. Significant error in the prediction of the PEFR will result if the effect of age is ignored, particularly in pubertal boys.
对339名7至16岁的英国学童测量了身高和呼气峰值流速（PEFR）。调查了他们过去的喘息或特应性病史、哮喘或特应性家族史，以及前两周内是否患感冒。发现PEFR与身高之间存在强相关性，可用方程PEFR = 5.640 Ht - 472.5表示（r = 0.89）。近期感冒以及个人或家族喘息或特应性病史阳性对回归方程均无显著影响。性别也不重要。对数据的进一步检查显示，年龄对呼气峰值流速有独立于身高的影响。年龄对女孩的影响呈线性，对男孩的影响呈曲线性。还对569名希腊学童进行了研究，发现年龄对呼气峰值流速与身高的回归有类似影响。这些发现的意义在于，任何关于儿童呼气峰值流速的人群研究都应确保每个身高区间的年龄分布正常。如果忽略年龄的影响，尤其是在青春期男孩中，将导致PEFR预测出现显著误差。
