Byeon Haewon, Lee Dongwoo, Cho Sunghyoun
Department of Speech Language Pathology & Audiology, School of Public Health, Nambu University, Gwangju, Republic of Korea.
Department of Physical Therapy, School of Public Health, Honam University, Gwangju, Republic of Korea.
BMJ Open. 2016 Nov 21;6(11):e012169. doi: 10.1136/bmjopen-2016-012169.
There is a possibility of underestimation in the smoking rate surveyed by self-reported questionnaires. This study investigated the difference between the Korean female smoking rate as determined by self-reports and that determined by a biochemical test and elucidated the relationship between women's smoking and laryngeal disorders.
Nationwide cross-sectional survey.
2008 Korea National Health and Nutrition Examination Survey.
1849 women who completed the health survey, urinary cotinine test and laryngoscope examinations.
This study defined smokers as those with urine cotinine contents of 50 ng/mL and over. Confounding factors included age, level of education, household income, occupation and problem drinking in the past year. For statistical tests, OR and 95% CI were presented by using complex samples logistic regression.
While there was no relationship between smoking as determined by a self-reported questionnaire and laryngeal disorders, smoking as determined by the urine cotinine test had a significant relationship with laryngeal disorders (p<0.05). After all the confounding factors were adjusted, those with urine cotinine concentrations of over 50 ng/mL had a 2.1 times higher risk of laryngeal disorders than those with urine cotinine concentrations of <50 ng/mL (OR=2.05, 95% CI 1.11 to 3.78) (p<0.05).
This national cross-sectional study verified that smoking is a significant risk factor for laryngeal disorders. Longitudinal studies are required to identify the causal relationship between smoking and laryngeal disorders.
通过自我报告问卷所调查的吸烟率有可能被低估。本研究调查了韩国女性自我报告的吸烟率与生化检测确定的吸烟率之间的差异，并阐明了女性吸烟与喉部疾病之间的关系。
全国性横断面调查。
2008年韩国国民健康与营养检查调查。
1849名完成了健康调查、尿可替宁检测和喉镜检查的女性。
本研究将吸烟者定义为尿可替宁含量≥50 ng/mL的人。混杂因素包括年龄、教育程度、家庭收入、职业以及过去一年中的问题饮酒情况。对于统计检验，采用复杂样本逻辑回归呈现比值比（OR）和95%置信区间（CI）。
虽然自我报告问卷确定的吸烟与喉部疾病之间没有关系，但尿可替宁检测确定的吸烟与喉部疾病有显著关系（p<0.05）。在对所有混杂因素进行调整后，尿可替宁浓度≥50 ng/mL的人患喉部疾病的风险是尿可替宁浓度<50 ng/mL的人的2.1倍（OR=2.05，95%CI 1.11至3.78）（p<0.05）。
这项全国性横断面研究证实吸烟是喉部疾病的一个重要危险因素。需要进行纵向研究以确定吸烟与喉部疾病之间的因果关系。
