Wang Pengyun, Li Juan, Li Hui-Jie, Huo Lijuan, Li Rui
Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
Front Aging Neurosci. 2016 Nov 7;8:260. doi: 10.3389/fnagi.2016.00260. eCollection 2016.
The present study conducted a quantitative meta-analysis aiming at assessing consensus across the functional neuroimaging studies of episodic memory in individuals with amnestic mild cognitive impairment (aMCI) and elucidating consistent activation patterns. An activation likelihood estimation (ALE) was conducted on the functional neuroimaging studies of episodic encoding and retrieval in aMCI individuals published up to March 31, 2015. Analyses covered 24 studies, which yielded 770 distinct foci. Compared to healthy controls, aMCI individuals showed statistically significant consistent activation differences in a widespread episodic memory network, not only in the bilateral medial temporal lobe and prefrontal cortex, but also in the angular gyrus, precunes, posterior cingulate cortex, and even certain more basic structures. The present ALE meta-analysis revealed that the abnormal patterns of widespread episodic memory network indicated that individuals with aMCI may not be completely "mild" in nature.
本研究进行了一项定量荟萃分析，旨在评估遗忘型轻度认知障碍（aMCI）个体情景记忆功能神经影像学研究的一致性，并阐明一致的激活模式。对截至2015年3月31日发表的aMCI个体情景编码和提取的功能神经影像学研究进行了激活可能性估计（ALE）分析。分析涵盖24项研究，产生了770个不同的焦点。与健康对照相比，aMCI个体在广泛的情景记忆网络中显示出具有统计学意义的一致激活差异，不仅在双侧内侧颞叶和前额叶皮质，还在角回、楔前叶、后扣带回皮质，甚至某些更基础的结构中。目前的ALE荟萃分析表明，广泛情景记忆网络的异常模式表明aMCI个体在本质上可能并非完全“轻度”。
